American Journal of Clinical Neurology and Neurosurgery
Articles Information
American Journal of Clinical Neurology and Neurosurgery, Vol.1, No.2, Sep. 2015, Pub. Date: Aug. 27, 2015
“Occult Renal Cell Carcinoma with Initial Presentation of Pulmonary Embolism and Cervical Vertebra Metastases”: Review
Pages: 117-120 Views: 2277 Downloads: 1159
Authors
[01] Ankit Bansal, Department of Neurosurgery, Neurosciences Centre, AIIMS New Delhi, India.
[02] Guru Dutta Satyarthee, Department of Neurosurgery, Neurosciences Centre, AIIMS New Delhi, India.
Abstract
Renal cell carcinoma presenting with pulmonary embolism is rare occurrence as evident by published few isolated case reports. However pulmonary embolism associated with compressive myelopathy as presentation is not reported. Authors reports a 32 – years - female who presented with complaints of rapidly progressing difficulty and shortness of breath along with numbness and spastic quadriparesis for seven days and also developing painful swelling involving right upper limb for 5 days. CT pulmonary angiography confirmed diagnosis of pulmonary embolism; Doppler study also revealed thrombosis of right basilic and cephalic veins and managed with anticoagulants. On further evaluation, she was detected to have mass lesion in right kidney and osteolytic lesion of C6 vertebral body. She underwent C6 corpectomy and anterior cervical plating followed by radical right nephrectomy. Our case is unique as it had both pulmonary embolism and cervical myelopathy as initial manifestation of renal cell carcinoma.
Keywords
Occult Renal Cell Carcinoma, Pulmonary Embolism, Surgery, Cervical Vertebral Osteolytic Lesion, Myelopathy
References
[01] Leibovich BC, Pantuck AJ, Bui MH, Ryu-Han K, Zisman A, Figlin R, Belldegrun. A Current staging of renal cell carcinoma. Urol Clin North Am 2003; 30 (3): 481-97.
[02] Ogunyemi O, Rojas A, Hematpour K, Rogers D, Head C, Bennett C. Metastasis of genitourinary tumors to the head and neck region. Eur Arch Otorhinolaryngol 2010; 267:273–279.
[03] Griffin N, Gore ME, Sohaib SA: Imaging in metastatic renal cell carcinoma Am J Roentgenol 2007; 189:360-370?
[04] Kozlowski JM. Management of distant solitary recurrence in the patient with renal cancer. Contralateral kidney and other sites. Urol Clin North Am 1994; 21:601-624.
[05] Curti BD. Renal cell carcinoma. JAMA 2004; 292:97-100.
[06] Bianchi M, Sun M, Jeldres C, Shari at SF, Trinh QD, Brigantine A, Tian Z, Schmitges J, Graefen M, Perrotte P, Menon M, Montorsi F, Karakiewicz PI (2012). Distribution of metastatic sites in renal cell carcinoma: a population-based analysis. Ann Oncol 2012; 23:973-80.
[07] Daughtry JD, Stewart BH, Golding LAR, Groves LK. Pulmonary embolus presenting as the initial manifestation of renal cell carcinoma. Ann Thorac Surg 1977; 24:178–181
[08] Gayer G, Mini S, Olchovsky D, Leibovitch I, Apter S, Weitzen R, Hertz M Pulmonary embolism initial manifestation of renal cell carcinoma in young woman. Emerg Radiol 2003; 10:43-5.
[09] King MB, Harmon KR Unusual forms of tumor embolism. Clin Chest Med 1994; 15:561–580.
[10] Schouten HJ, Geersing GJ, Koek HL, Zuithoff NP, Janssen KJ, Douma RA, van Delden JJ, Moons KG, Reitsma JB Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta- analysis. BMJ 2013; 346: 2492.
[11] Trujillo-Santos J, Monreal M (2013) Management of unsuspected pulmonary embolism in cancer patients. Expert Rev Hematol. 2013; 6:83-88.
[12] Arguello F, Baggs RB, Duerst RE, Johnstone L, McQueen K, Frantz CN (1990). Pathogenesis of vertebral metastasis and epidural spinal cord compression. Cancer 1990; 65:98–106.
[13] Alessandro Gasbarrini, Christiano Esteves Simões, Michele Cappuccio Stefano Boriani. Management of Renal Cell Carcinoma Metastasis of the Spine, Emerging Research and Treatments in Renal Cell Carcinoma, Dr. Robert Amato (Ed.), 2012; 311-335.
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