Bioscience and Bioengineering
Articles Information
Bioscience and Bioengineering, Vol.5, No.1, Mar. 2019, Pub. Date: Jan. 25, 2019
Evaluation of Anti-malarial Drugs Use in Gbadolite Health Area in Democratic Republic of the Congo: A Cross-Sectional Study
Pages: 1-10 Views: 360 Downloads: 240
Authors
[01] Koto-Te-Nyiwa Ngbolua, Faculty of Medicine, University of Gbadolite, Gbadolite City, Democratic Republic of the Congo; Faculty of Science, University of Kinshasa, Kinshasa City, Democratic Republic of the Congo; Environment Management and Geography Department, Higher Pedagogical Institute of Abumombazi, Abumombazi, Democratic Republic of the Congo; Faculty of Science, University of Gbadolite, Gbadolite City, Democratic Republic of the Congo.
[02] Guy Ngambika Kumbali, Faculty of Medicine, University of Gbadolite, Gbadolite City, Democratic Republic of the Congo.
[03] Christian Amisi Motuta, Faculty of Medicine, University of Gbadolite, Gbadolite City, Democratic Republic of the Congo.
[04] Colette Masengo Ashande, Faculty of Science, University of Gbadolite, Gbadolite City, Democratic Republic of the Congo.
[05] Benjamin Zoawe Gbolo, Faculty of Science, University of Kinshasa, Kinshasa City, Democratic Republic of the Congo; Faculty of Science, University of Gbadolite, Gbadolite City, Democratic Republic of the Congo.
[06] Gédéon Ngiala Bongo, Faculty of Science, University of Kinshasa, Kinshasa City, Democratic Republic of the Congo; Faculty of Science, University of Gbadolite, Gbadolite City, Democratic Republic of the Congo.
[07] Ruphin D. Djolu, Faculty of Science, University of Gbadolite, Gbadolite City, Democratic Republic of the Congo.
[08] Janvier Mukiza, Faculty of Medicine and Surgery, University of Gitwe, Nyanza, Rwanda.
[09] Pius Tshimankinda Mpiana, Faculty of Science, University of Kinshasa, Kinshasa City, Democratic Republic of the Congo.
Abstract
Gbadolite health area is located in the Ubangi eco-region where Malaria is hyper-endemic stable with a perennial transmission. The aim of this study was to evaluate the anti-malarial drugs use in this health area in Nord Ubangi Province, Democratic Republic of Congo. A retrospective cross-sectional study design was conducted using selected patient cards from January 2016 to December 2017. 400 patient records have been randomly selected and analyzed. Obtained results indicate that 69% of patients are between 6 and 71 years old, and 31% of cases are children under 5 years. 56% of patients are male compared to 44% of female. 63% of patients are literate while 37% are illiterate. The majority of anti-malarial drugs prescribers are physicians (54%) followed by nurses (46%). 54% of cases concern simple malaria, 37% of cases, severe malaria and 9% of cases concern other pathologies. However, the rapid diagnostic test for confirmation indicates that 46% of those surveyed have simple malaria, 37% have severe malaria, and 17% have other diseases (diabetes, ulcer, dermatitis and cardiovascular disease). Seven types of anti-malarials drugs (alone or combined: Cether-L®, Artemether, Artesun®, ACT, Quinine, Co-artem® and ARH-L forte®) are used in Gbadolite city. The tablet is the most commonly used pharmaceutical form (51%) followed by the injectable form (47%) and syrup (2%). These AMD are associated with antibiotics (35% of cases), vitamins (20%), anti-helminthics (19%) and anti-cough (4%). In 94% of cases, the dose of anti-malarials administered to patients is consistent. However, in 4% of cases, there is overdose while the sub-dose is estimated at 2% of cases. Based on current knowledge, this is a first report concerning cross-sectional study on the use of antimalarial-based drugs in Gbadolite health area and revealed that the use of anti-malarial drugs is not fully in agreement with the guideline despite good practice.
Keywords
Malaria, Artemisinin-Based Combination Therapy, Survey, Pharmaco-Vigilance, Gbadolite
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