Clinical Medicine Journal
Articles Information
Clinical Medicine Journal, Vol.1, No.4, Oct. 2015, Pub. Date: Oct. 27, 2015
Hematological Parameters of Malnourished Sudanese Children Under 5 Years – Khartoum State – 2011
Pages: 152-156 Views: 1106 Downloads: 533
Authors
[01] Haider Mohammed Basheir, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
[02] Khalda Mirghani Hamza, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
Abstract
Malnutrition is one of health problems in developing countries in particular. Maternal and child health centers are often not available in many areas in Sudan. This study aimed to determine complete blood count of malnourished Sudanese children bellow 5 years of age (2011). 27 males and 23 females malnourished pediatric patients were enrolled in this study. Twenty apparently healthy with matched age subjects were selected as control group. An informed consent was obtained from participants parents before blood sample collection. Five ml venous blood was collected from each participant, 2.5 ml was collected in EDTA container for CBC determination, and 2.5 ml was collected in plain container for serum iron and serum ferritin measurement. Hematological analyzer Sysmex KX 21N was used for CBC measurement. A-25 Biosystem was used for determination of serum iron. SPSS software program was used for statistical analysis, significance level was set at p ≤ 0.05. 58% of test group with age bellow 18 months and 42% above 18 months. Marasmus was observed in 82% of malnourished children. ALL hematological parameters of malnourished children was significantly different compared to control group. Hemoglobin decreased from 15.12 ±1.1 g/dl in control group to 8.8 ± 2.5 g/dl in test group. Blood platelet count and WBC of test group significantly increased compared to control (p < 0.00). WBC increased from 5.1 ± 0.98 × 103 µl in control to 12.2 ±5.2 ×103 in test group. Serum iron and serum ferritin of malnourished children significantly decreased compared to control group. Serum iron decreased from 99.3 ± 27.6 µg/ dl to 43.9 ± 32.9 µg/ dl in control and test groups respectively (p < 0.00). In conclusion, marasmus is the major type of malnutrition among study group. Malnutrition significantly alters hematological status of test group. Iron deficiency and infections are frequently associated with malnutrition.
Keywords
Malnutrition, Marasmus, Hemoglobin, Iron, Ferritin
References
[01] Katona P, and Katona J. The Interaction between Nutrition and Infection. Oxford Journal Medicine and Health 2008;46(10):1582-1588.
[02] Page A, de Rekeneire N, Sayadi S, et al. Infection of Children Admitted with Complicated Severe Acute Malnutrition (SAM) in Nigeria PMC 2013;8 (7): e68699.
[03] Muoneke V, Ibekwe R, U Nebe-Agumadu H et al. Factors Associated with Mortality in Under – five children with Severe Anaemia in Ebonyi Nigeria J Indian Pediatr. 2012; 49: 119-123.
[04] Fageer S A, Karrar A H and AL Hag S M. Assessment of Plasma Levels of Proteins, total cholesterol and high density lipo-protein cholesterol in Sudanese Malnourished Children. Journal of Science and Technology 2013;14: ISSN- 1605-427 X.
[05] Rabinowitz S S. Marasmus. Drugs and Disease. medicine. Medscape. 2014.
[06] Chotard S, Mason J, Oliphant N et al.Assessment of Child Nutrition in the Greater Horn of Africa: Recent Trends and Future Development. Unicef Report 2006.
[07] Abdelgader A M, Abdulla S H and Kordofani A Y. Plasma Homcysteine Levels in Cardiovascular diseases, malaria and PEM in Sudan. Eastern Mediterian Health Journal 2009;15: 1432- 1439.
[08] Fredrick F and Valentine G. Improvised Peritoneal Dialysis in an 18 – months – old child with severe acute malnutrition (kwashiorkor) and acute kidney injury: a case report. Journal of Medical Case Report 2013;7:168.
[09] Bachou H, Tylleskar T, Downing and Tumwine J. Severe Malnutrition with and without HIV – infection in hospitalized children in Kampala, Uganda: differences in clinical features, haematological findings and CD4+ cell count. Nutrition Journal 2006; 5: 27.
[10] Omuderman Pediatrics Hospital – Statistical Services. Cases of malnutrition Children attended Omuderman Pediatrics Hospital (2005 – 2011).
[11] Unicef Data – New Notes (current status and progress). New data on child malnutrition in Sudan a gold mine. 2014.
[12] University of Maryland Medical Center (UMMC). Anemia. An in depth report on the types, diagnosis, treatment and prevention of anemia. 2015; 21201.1.800.492.5538TDD:1.800:735. Baltimore.
[13] Tine R CK, Ndiaye M, Hansson H, Ndour C et al. The Association between Malaria, Parasitaemia, erythrocyte polymorphism and Anemia in Children less than 10 years in Senegal: a case control study. BMC Research Notes. 2012; 5: 565.
[14] Ahmed S, Hassan M and Ahmed W. Socio-economic Inequity among Under – Five Children and Women at Reproductive Age in Bangladesh. Journal of Nutrition and Health 2013; 1(2): 18-22.
[15] Rahman A, Mann MA and Rahman MH. Influence of Infection on Iron Profile in Severly Malnourished Children. Indian J Pediatr / PubMed 2009; 76 (9): 907-911.
[16] Clark M A, Goheen M M and Cerami C. Influence of Host Iron status in Plasmodium falciparum Infection. Review Article. http:// dx.doi.org/10.3389/fphar.2014.00084. North Calorina.
[17] Essien EM, OFR, FAS, NMOM, FWACP. Platelets Abnormalities in Experimental Malaria - Review. Nigerian Journal of Clinical and Biochemical Research 2006; 1(1): 15- 18.
[18] Speth C, Loffler J, Krappmann S, et al. Platelets as Immune Cells in Infectious Diseases. Future Microbiology 2013; 8 (11): 1431-1451.
[19] Under A, Caliskan U, Oner AF et al. Platelet Functions in Patients with PEM. J Clinical Appl. Thrombo Hemost 2001; 7 (4): 286 - 288.
[20] Ernest N, Akpan P and Emmanuel UKO. Reduced Levels of Some Iron Parameters of PEM Malnourished Children. Journal of Biology, Agriculture and Health Care 2103; 3 (13): 114-120.
[21] Health grades Editorial Staff. Marasmus. Food, Nutrition and Diet. Medical Reviewers: William C., Lloyd III, MD, FACS; 2013.
[22] Soka Aa, Bilamin Sa, Lalubosun L et al. Hematological Profile in Children with PEM in North Nigeria. Journal of Medical Research 2012; 12 (4): 1-7.
[23] Jones K D and Berkley J A. Severe Acute Malnutrition and Infection (SAM). PMC Journal Ann Trop Pediatr 2014; 34 (1): 1-29.
[24] Rahman A, Mann MA and Rahman MH et al. Influence of Acute Respiratory Infection on Iron Profile in Severely Malnourished Children. PubMed - Mymeningh M Journal 2008; 17 (2): 552 - 8 India.
[25] Oppenheimer S J. Iron – Deficiency Anemia: Reexamining the Nature and Magnitude of the Public Health Problem. Iron and its Relation to Immunity and Infectious Disease. Journal of Nutrition 2001; 131: 616S - 635S.
[26] Malhotra R. K., Saraya A. K., Kumar R. et al., Platelet Aggregation in Iron Deficiency Anemia 1985; 52 (2): 139-145.
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