Clinical Medicine Journal
Articles Information
Clinical Medicine Journal, Vol.1, No.5, Dec. 2015, Pub. Date: Dec. 6, 2015
Fibrinogen Plasma Level, Platelet Count and Mean Platelet Volume of Sudanese Diabetic Patients with Retinopathy
Pages: 157-161 Views: 774 Downloads: 538
Authors
[01] Khalda M irghani Hamza, Department of Hematology and Immunohematology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
[02] Walla ie Alla Omer Ahmed Wag, Department of Hematology and Immunohematology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
Abstract
Diabetes mellitus is a carbohydrates disorder and is often associated with micro-vascular complications in particular which causes hemostatic abnormalities. This is a case control study conducted in Fedial Hospital Khartoum State during the period from June to October 2013. The study aimed to determine plasma fibrinogen level, platelet count and mean platelet volume (MPV) of diabetic patients (type 2) with retinopathy, 32 were males and 18 were females 150 were enrolled in the study with age ranged between 40-69 years, 50 of them were diabetic patients with retinopathy, mean age 52.7 ± 7.5 years, 50 were type 2 diabetes mellitus patients with mean age of 54.8 ± 8.5 years and 50 were non diabetic apparently healthy subjects with mean age was and 53.3 ± 7.9 years. Five ml venous blood was collected from each participant, 2.5 ml was collected in tri-sodium citrate container and poor platelet plasma was obtained. Stago coagulation analyzer was used to measure plasma fibrinogen level. The remaining 2.5 ml was collected in EDTA container and Sysmex autoanalyzer was used to measure platelet count and mean platelet volume. The results showed significant increase in plasma fibrinogen level in diabetic patients with retinopathy compared to both diabetic and control groups. Fibrinogen level increased from 278.3 ± 48.4 mg/dl in control group to 371.6 ± 56.6 mg/dl in diabetic patients with retinopathy. No significant difference in platelet count of diabetic patients with retinopathy and the other two groups. Mean platelet volume significantly increase from 10.1 ± 0.88 fl in diabetic patients to 11.2 ± 0.7 fl in diabetic patients with retinopathy. According to duration of diabetes mellitus, no significant difference was observed in fibrinogen level, blood platelet count or MPV. Elevation of fibrinogen plasma level and MPV indicated that diabetic patients are prone to hemostatic abnormalities irrespective of diabetes mellitus onset.
Keywords
Fibrinogen, Diabetes Mellitus, Retinopathy, Mean Platelet Volume
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