Clinical Medicine Journal
Articles Information
Clinical Medicine Journal, Vol.2, No.3, Jun. 2016, Pub. Date: Aug. 5, 2016
Hematological Profile of Patients with Visceral Leishmaniasis at Al-Gaderf State - Sudan
Pages: 31-39 Views: 762 Downloads: 292
[01] Amna El-Sadig El–Safi, Department of Hematology and Immune-Hematology, College of Medical, Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
[02] Al-Sara Khalid Adm, Department of Hematology and Immune-Hematology, College of Medical, Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
[03] Khalda Mirghani Hamza, Department of Hematology and Immune-Hematology, College of Medical, Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
This is a case control study conducted during the years (2010-2011) at Al-Gaderf Teaching Hospital, Sudan. The objective of the study is to assess the hematological profile of patients with Visceral Leishmaniais admitted to Al-Gaderf Teaching Hospital. The patients were divided into 2 groups; group A: paediatric Visceral Leishmaniasis 50 patients under 14 years old, 33 (66%) were males and 17 (34%) were females. Complete Blood Cell Count was determined using fully automated hematological analyzer Sysmex KX 21N. Group B included 50 visceral leishmaniasis patients with different age groups, 26 (52%) were males and 24 (48%) were females. Hemostatic profile was determined manually determined. An informed consent was obtained from gardeners of paediatric patients and directly obtained from adult patients. Most affected paediatric patients with age less than 10 years. Among adult patients the most frequent age group ranged between 21 and 30 years. Both Males and females were infected, but males showed higher frequency. Significant decrease was observed in Hb and RBC of paediatric patients (7.2 ± 1.6 g/dl and 3.6 ± 0.7×106 µl respectively compared to control group (12.3 ± 1.1 g/ dl and 4.7 ± 0.4 ×106 µl respectively). Total WBC count and neutrophil percent decreased significantly (p-value=0.000). Thrombocytopenia was also observed in patients in both groups (p-value= 0.000). Significant prolongation in PT and APTT of group B patients was observed compared to control subjects; TT was also prolonged but insignificantly. In conclusion, Visceral Leishmaniasis affects children and young adults.
Visceral Leishmaniasis, Anemia, Leukopenia, Coagulopathy
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