Clinical Medicine Journal
Articles Information
Clinical Medicine Journal, Vol.2, No.3, Jun. 2016, Pub. Date: Aug. 5, 2016
Hematological Profile of Patients with Visceral Leishmaniasis at Al-Gaderf State - Sudan
Pages: 31-39 Views: 762 Downloads: 292
Authors
[01] Amna El-Sadig El–Safi, Department of Hematology and Immune-Hematology, College of Medical, Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
[02] Al-Sara Khalid Adm, Department of Hematology and Immune-Hematology, College of Medical, Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
[03] Khalda Mirghani Hamza, Department of Hematology and Immune-Hematology, College of Medical, Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
Abstract
This is a case control study conducted during the years (2010-2011) at Al-Gaderf Teaching Hospital, Sudan. The objective of the study is to assess the hematological profile of patients with Visceral Leishmaniais admitted to Al-Gaderf Teaching Hospital. The patients were divided into 2 groups; group A: paediatric Visceral Leishmaniasis 50 patients under 14 years old, 33 (66%) were males and 17 (34%) were females. Complete Blood Cell Count was determined using fully automated hematological analyzer Sysmex KX 21N. Group B included 50 visceral leishmaniasis patients with different age groups, 26 (52%) were males and 24 (48%) were females. Hemostatic profile was determined manually determined. An informed consent was obtained from gardeners of paediatric patients and directly obtained from adult patients. Most affected paediatric patients with age less than 10 years. Among adult patients the most frequent age group ranged between 21 and 30 years. Both Males and females were infected, but males showed higher frequency. Significant decrease was observed in Hb and RBC of paediatric patients (7.2 ± 1.6 g/dl and 3.6 ± 0.7×106 µl respectively compared to control group (12.3 ± 1.1 g/ dl and 4.7 ± 0.4 ×106 µl respectively). Total WBC count and neutrophil percent decreased significantly (p-value=0.000). Thrombocytopenia was also observed in patients in both groups (p-value= 0.000). Significant prolongation in PT and APTT of group B patients was observed compared to control subjects; TT was also prolonged but insignificantly. In conclusion, Visceral Leishmaniasis affects children and young adults.
Keywords
Visceral Leishmaniasis, Anemia, Leukopenia, Coagulopathy
References
[01] Neelam Varma and Shano Naseem. Hematological Changes in Visceral Leishmaniasis/Kala Azar. Indian Journal of Hematology and Blood Tranfusion 2010, 26 (3): 78-82.
[02] Piet A. Kager. Leishmania species (Leishmaniasis). Leishmaniasis- Infectious Disease and Antimicrobial Agents. Am J Trop Med Hy 2014; 91: 901-4.
[03] Sara E. J. Cotterell, Christian R. Engwerda and Paul M. Kaye. Leishmaniasis donovani Infection of bone marrow stromal macrophages selectively enhances myelopoiesis, by a mechanism involving GM-CSF and TNF- α. Blood 2000; 95 (5): 1642-1651.
[04] Centre of Food Security and Public Health- Iowa State University. Institute for International Cooperation in Animal Biologics 2009: 1-11.
[05] P Ngure, A Kimutai, W Tonui, Z Nganga. A Review of Leishmaniasis in Eastern Africa. Original Article. The internet Journal of Parasitic Diseases. 2008; 4 (1).
[06] Abdolvahab Alborzi, Gholam Reza Pouladfar, Mohammed Hassan Aelami. Visceral Leishmaniasis; literature review and Iranian experience. Iranian Journal of Clinical Infectious Diseases 2007; 2(2): 99-108.
[07] Ali Fattahi Bafghi, Seyed Hossein Shahceraghi, Sedigheh Nematollahi. Comparison of Hematological Aspects: Visceral Leishmaniasis and Healthy Children. Tropical Parasitology 2015, 5(2): 133-135.
[08] Mohamed Maroof Middib, Fadil Abass Al- Mouktar. Hematological Changes including the Immune system in Patients with Visceral Leshmaniasis at Al-Muthanna Governorate; Journal of Babylon University/ Pure and Applied Sciences/ No. (4)/ 22: 2014.
[09] Carlos Henrique Nery Costa, Guilnerme Loureiro Werneck, Drcas Lamounier et al. Is Severe Visceral Leishamniasis a systemic Response Syndrome? A case Control Study. Soc. Bras. Med. Trop 2010.43 (4).
[10] Sameer Gulati, HP Paljor, Sanjay Panadit, et al.. Kala Azar without Splenomegaly. Annals of Tropical Medicine and Public Health 2009; 2 (2): 57-60.
[11] Omaima Abd ELsied A. and Mahdi H. A. Abdalla. Visceral Leishmaniasis: Hematological and Hemostatic Changes among Sudanese Patients. International Journal of Current Research 2014; 6 (12): 11037-11039.
[12] Carson-Dewitti, Rosaly; Odle, Tersa. Leishmaniasis. Gale Encyclopedia of Medicine, 3rd ed. 2006. http://www.encyclopedia.com 2015.
[13] Gamal Abdul Hamid, Ghada A. Gobah. Clinical and Hematological Manifestation of Visceral Leishmaniasis in Yemen Children. Turk J Hematol 2009; 26: 25-8.
[14] Talh Burki. East African Countries Struggle with Visceral Leishmaniasis; World Report. The Lancet 2009; 374(9687): 371-372.
[15] Bahdor Sarkari, Tahereh Naraki, Mohammad Amin Ghatee et al. Visceral Leishmaniasis In Southern western Iran: A Retrospective Clinico-Hematological Analysis of 380 Consecutive Hospitalized Cases (1999-2014). PlOS ONE Neg Trop Dis 2016; 11(3).
[16] Kafetzis D A. An Overview of Pediatric Leishamniasis. PubMed SYMPOSIUM 2003; 49(1): 31-8.
[17] Ruma Pahwa, Sanjeer Kumar Gupta, Tejinder Singh et. al. Acute Fulminant Visceral Leishmaniasis in Children – A report of Two Cases. Indian Journal of Pathology and Microbiology 2004; 47(3): 428-430.
[18] Lomtaze ML, Khochava MA, Shalamberidze IA et al. Study of Intravenous Coagulation Activation markers in Patients with Visceral Leishmaniasis. Georgian Med News 2005; (124-125): 47-50.
[19] Lomtadze ML, Khochava MA, Shalamberidze IA et al. Functional Status of Hemostasis System in Patients with Visceral Leishmaniasis PubMed Georgian Med News 2005; (128): 59-62.
[20] Guha R, Das S, Ghosh J, Naskar K et al. Heterologus priming-boosting with DNA and Vaccinia virus expressing kinetoplastid membrane protein – 11 Induces potent cellular Immune response and confers protection against infection with antimony resistant and sensitive strains of Leishmania donovani. PubMed Vaccine 2013; 31(15): 1905-15.
[21] Rajiv Kumar and Christian Engwerda. Vaccines to prevent Leishmaniasis. Clinical and Translation Immunology 2014; 3.
[22] Jain K and Jain NK. Vaccines for Visceral Leishmaniasis: A review J Immunol Methods 2015; 422: 1-12.
[23] Muhammad O. Al- Muhammadi, Gafil S. Hassan Al- Shujiri and Mudar H. Noor. Hematological changes in children suffering from Visceral Leishmaniasis (Kalaz-azar). Medical Journal of Babylon 2004; 1(3 and 4) pp: 325.
[24] Muhammad O. Al- Muhammadi, Gafil S. Hassan Al- Shujiri and Mudar H. Noor. Hematological changes in children suffering from Visceral Leishmaniasis (Kalaz- azar). Medical Journal of Babylon 1:4, 2014: doi: 1812-156X1-4.
[25] Zainab H., Meaad K. Hassan and Abdul Mohsin H. Jassim. Outcome of Hospitalized Children with Visceral Leishmaniasis in Basrah, Southern Iraq. The Medical Journal of Basrah University 2008; 26(2): 121-126.
[26] Erika van den Bogaart, Al- Badawi A Talha, Masja Straetemans et al. Cytokine Profile Amongst Sudanese Patients with Visceral Leishmaniasis and Malaria co-infection. BMC Immunology 2014; 14 (16): doi: 10.1186/ 1471-2172-15-16.
[27] Zeinab Hameed Gani, Meaad Kadhum Hassan- Abdul- Mohsin Hameed Jassim. Infectious Complications of Visceral Leishmaniasis in Basrah Iraq. Kerbala Journal of Medicine 2011; 4 (1): 972-979.
[28] H A M N Ahasan, FCPS, M A J Chowdhury, FCPS, et al. Deaths in Visceral Leshimanaisis (Kala-azar) During Treatment. Original article Med J Malaysia1996; 51(1): 29-32.
[29] Agrawal Y., AK Sinha, P Upadhyaya et al. Hematological Profile in Visceral Leishmaniasis. International Journal of Infection and Microbiology 2013; 2(2): 39-44.
[30] Elfakey Walyeldin, Ahmed Muawia Abdurrahman and Suwar M. Children with Visceral Leishmaniasis Presented to Omdurman Emergency Hospital for Children. Sudanese Journal of Paediatrics and Child Health 2010; 10: 46-50.
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