Clinical Medicine Journal
Articles Information
Clinical Medicine Journal, Vol.2, No.4, Aug. 2016, Pub. Date: Aug. 5, 2016
Hematological Profile of Sudanese Patients with Systemic Lupus Erythematosus
Pages: 40-45 Views: 1451 Downloads: 1620
[01] Khalda Mirghani Hamza, Department of Hematology and Immunohematology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
[02] Zeinab Mohamed Bashir, Department of Hematology and Immunohematology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan.
This is a case control study aimed to evaluate hematological status of Sudanese female patients with Systemic Lupus Erythematous. The objective off the study is to assess hematological profile of Sudanese patients with Systemic Lupus Erythematosus. Fifty SLE patients and 50 apparently healthy females were enrolled in the study. Age of participants ranged from 18 to 62 years with 64% with age less than 40 years. Hb was 11.2 ± 1.9 g/dl compared to 12.7 ± 1.1 g/dl in control group (p = 0.000). RBC and PCV significantly decreased (p = 0.000, 0.003) respectively. Neutrophils count was 4.1 ± 2.1× 103 µl compared to 3.0 ± 1.1× 103 µl in control group. Anemia and infection are frequent among SLE patients. Thrombocytes remained within normal range. In conclusion, most common age of SLE patients ranged between 18 and 40 years.
Systemic Lupus erythematosus, Hemoglobin, Anemia, Neutrophilia
[01] Daniel J Wallace. Diagnosis and differential diagnosis of systemic lupus Erythematosus. 2015. Wolters Kluwer.
[02] Mumatz Ali Shakih, Igbal Memon and Rafi Ahmed Ghori. Frequency of Anemia in Patients with systemic lupus erythematosus at Tertiary Care Hospital. Journal of Pakistan Medical Association JPMA 2010; 60: 822.
[03] Robert G. Lahita. Systemic Lupus Erythematosus. 4th edition. International Standard Book 0-12-433901-8. 2004. Elsevier Academic Press.
[04] Babikir G K, Abubakr A W, Musa M N, et al. Ethnic distribution and clinical features of Systemic lupus erythematosus. Sudan Medical Journal 2009; 45(2): 49-57.
[05] Rudrajit P, Pradip R, Pradip K S, et al. Prevalence of Systemic Lupus Erythematous Among patients of hyperthyroidism in a tertiary care centre. Indian Journal Endocrinol Metab 2012; 16(4): 569-574.
[06] Frances R, Michael D, Mathew G, et al. The Incidence and Prevalence of Systemic Lupus Erythematous in UK. 1999-2012. Ann Rheum Dis 2014; doi: 10.1136/ annrheum- 2014- 206334.
[07] Somers EC, Marder W, Caqnoli P, et al. Population – based incidence and Prevalence of Systemic lupus erythematosus. Journal of Arthritis Rheumatol 2014; 66(2): 369-378.
[08] Flower C, Hennis AJ, Hamblton IR, et al. Systemic Lupus Erythematosus in an African Caribbean population: incidence, clinical manifestations and survival In the Barbados National Lupus Registry. PubMed. Arthritis Care Res 2012; 64 (8): 1151-1158.
[09] S. Sam Lim, A. Rana Bayakly, Charles G. H, et al. The Incidence and Prevalence of SLE 2002-2004. The Georgia Lupus Registry. Journal Arthritis and Rheumatology 2014; 66(2): 357-368.
[10] Arnaud, Laurent, Fagot, et al. Incidence and Prevalence of SLE A 2010 Nation – Wide Population – Based Study using French National Administrative Database. Journal Arthritis and Rheumatoid 2013; 65(10): 1067.
[11] Peter H Schur, and Bevara H Hahh. Epidemiology and Pathogenesis of SLE 2015. Updated 2015.
[12] Hassan A A Eltom, Hyder O M, Tayseer H A, et al. Clinical Implications of the Presence of Anti Ro Antibodies in Systemic Lupus Erythematosus in Sudan. Sudan Journal of Medical Sciences 2015; 10(3): 93-98.
[13] Molokhia, M; MC Keigue, PM; Caudrado, M; Hughes, et al. Systemic Lupus Erythematous in Migrants from West Africa compared with Afro-Caribbean people. Lancet 2001; 357(9266): 1414-5.
[14] Shaikh M A, Jehangir S and Rizwan C. Various Modes of Presentation of Systemic Lupus Erythematosus at a Tertiary Care Hospital. Original Article. Medical Channel (MC) 2011; 17(2): 42-45.
[15] Janoudi Nahid and Bardisi Ekhlas S. Hematological Manifestations in Systemic Lupus Erythematosus. Saudi Arabia. Text book. ISBN 978-953-51- 0266-3. 2012 Publishers: In Tech. Chapter 17: 364-382.
[16] Arthur K. Thrombocytopenia Assed with Systemic Lupus Erythematosus. Medscape Rheumatology 2001; 3(1).
[17] M. Kuwana, J. Kaburaki, Y. Okazaki, H. Miyazaki and Y. Ikeda. Two types of Autoantibody- mediated thrombocytopenia in patients with systemic lupus erythematosus. Oxford Journals Medicine and Health Rheumatology 2006; 45(7): 851-854.
[18] Kamoltip L, Nuntana K, Suparaporn W, et al. An Evaluation of the Association of Leukopenia and Severe infection in Patients with Systemic Lupus Erythematosus. J. Clin Rheumatol 2013; 19 (30): 115-120.
[19] Michalis V, Styliani I G Kokori, John P A Loannidis, et al. Anemia in Systemic Lupus Erythematous: etiological profile and the role of erythropoietin. Ann Rheum Dis 2000; 59: 217-222.
[20] S Giannouli, M Voulgarelis, P D Ziakas and A G Tzioufas. Anemia in Systemic Lupus Erythematosus: from Pathophysiological to Clinical Assessment. Annals of the Rheumatic Diseases 2006; 65(2): 144-148.
[21] Hirano, Y., Itonaga, T., Yasudo, H, et al. Systemic lupus erythematosus Presenting with Mixed-type fulminant autoimmune hemolytic anemia. Paediatrics International. 2016. doi: 10.1111/ped.12849.
[22] Murdaca G, Orsi A. Spano F, et al. Vaccine – preventable infections in Systemic Lupus Erythematous. Hum Vaccin Immunother 2016. PubMed.
[23] D. Martinez-Banos, J. C. Crispin, A. Lazo and J. Sanchez-Guerrero Moderate and Severe Neutropenia in Patients with Systemic Lupus Erythematosus. Rheumatology 2006; 45(8): 994-998.
[24] Nick Ward. Autoimmunity: The Role of Neutrophils in SLE untangling the Net. Nature Review Rheumatology 2011; 7: 252.
[25] H Al-Hadithy, D A Isenberg, I E Addison, et al. Neutrophils Function in Systemic Lupus Erythematosus. Ann Rheum Dis 1982; 41(1): 33-38.
[26] Roberto L, Dipyaman G, Valeria F, et al. Neutrophils Activate Palsmacytoid Dendritic Cells by Release Self- DNA – Peptide Complexes in Systemic Lupus Erythematosus. Science Translation Medicine 2011; 3(73): 73ra19.
[27] Alastair L. Hepburn, Santosh N and Justin C Mason. The Management of peripheral Blood cytopenias in Systemic Lupus Erythematosus. Rheumatology 2010; 49(12): 2243-2254.
[28] Carolyne K S and Mariana K. The Role of Neutrophils in the Pathogenesis of Systemic Lupus Erythematosus. PubMed. Current Opinion in Rheumatology. 2015; 27 (5).
[29] Linda C, Chiara, Sabrina V, et al. Leukopenia, Lympnopenia and Neutropenia in Systemic Lupus Erythematosus: Prevalence and Clinical Impact. 2015; 45(2): 190-194. doi: http://dx.doi-org/ 10.1016/I: Semarthrit. Elsevier.
[30] Bashal F. Hematological Disorders in Patients with Systemic Lupus Erythematosus. Open Rheumatol Journal 2013; 7: 87-95.
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