Clinical Medicine Journal
Articles Information
Clinical Medicine Journal, Vol.1, No.1, Apr. 2015, Pub. Date: Apr. 8, 2015
Malignant Gastrointestinal Stromal Tumour of the Prostate - a Case Report
Pages: 13-16 Views: 1537 Downloads: 403
Authors
[01] S. Gopalswamy, Department of Urology, Royal Cornwall Hospital, Truro, United Kingdom.
[02] J. S. O’Rourke, Department of Urology, Royal Cornwall Hospital, Truro, United Kingdom.
[03] J. Mathew, Department of Pathology, Royal Cornwall Hospital, Truro, United Kingdom.
Abstract
Gastrointestinal stromal tumour (GIST) of the prostate is a very rare entity and only two such cases are reported in the literature. We report a case of GIST of the prostate in a 69 year old gentleman who had transurethral resection of the prostate (TURP) for benign prostatic hyperplasia (BPH) 7 years ago and subsequently presented with acute urinary retention from re-growth of the prostate. The prostate specific antigen level was 4 ug/l. The re-do TURP specimen showed the characteristic features of GIST, both microscopic and immunoprofile analysis. The possibility of secondary gastrointestinal GIST was excluded by endoscopy, imaging and tumour markers.
Keywords
GIST, Prostate, Urinary Retention, Imatinib
References
[01] Chii-Hong Lee, Yun-Ho Lin, Hsia-Yu Lin et al. Gastrointestinal stromal tumor of prostate: a case report. Human pathology (2006) 37, 1361-1365.
[02] Hansel DE, Herawi M, Epstein JI. Spindle cell lesions of the prostate. Mod Pathol. 2007 Jan;20(1):148-58.
[03] Miettinen M, Majidi M, Lasota J. Pathology and diagnostic criteria of gastrointestinal stromal tumours: a review. Eur J Cancer. 2002 sep; 38 Suppl 5:S39-51.
[04] Miettinen M, Lasota J. Gastrointestinal stromal tumours:pathology and prognosis at different sites. Semin Diagn Pathol.2006 may; 23(2):70-83.
[05] Miettinen M, Monihan JM, Sarlomo-Rikala M. Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: Clinicopathologic and immunohistochemical study of 26 cases. Am. J. Surg. Pathol. 1999; 23: 1109–18.
[06] Reith JD, Goldblum JR, Lyles RI. Extragastrointestinal (soft tissue) stromal tumors: An analysis of 48 cases with emphasis on histologic predictors of outcome. Mod. Pathol. 2000; 13: 577–85.
[07] Van der Aa F, Sciot R, Blyweert W. Gastrointestinal stromal tumor of the prostate. Urology2005; 65: 388.
[08] Miettinen M, Lasota J. Gastrointestinal stromal tumours: review of morphology, molecular pathology, prognosis and differential diagnosis. Arch Pathol Lab Med. 2006 Oct;130(10):1466-78.
[09] Rosai J. Gist:an update. Int J Surg Pathol 2003;11:177-86.
[10] Dow N, Giblen G, Sobin LH, et al. GIST: differential diagnosis. Semin Diagn Pathol. 2006 may;23(2):111-9.
[11] Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol 2002;33:459–465.
[12] Miettinen M, El Rifai W, Sobin HL, et al. Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol 2002; 33:478–483.
[13] Koay MH, Goh YW. Segal A et al. GISTs:a clinicopathological and molecular study of 66 cases. Pathology. 2005 Feb;37(1):22-31.
[14] Croom KF, Perry CM. Imatinib mesylate:in the treatment of GISTs. Drugs.2003;63(5):513-22.
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