Clinical Medicine Journal
Articles Information
Clinical Medicine Journal, Vol.1, No.2, Jun. 2015, Pub. Date: May 18, 2015
Hematologic Toxicity of Temozolomide and Radiation in Glioblastoma Patients – Correlation with Clinicopathological Factors
Pages: 63-69 Views: 1549 Downloads: 775
Authors
[01] Martina E. Becker-Schiebe, Department of Radiotherapy and Radio-Oncology, Klinikum Braunschweig, Hannover Medical School, Braunschweig, Germany; Radiation Oncology, Hannover Medical School, Hannover, Germany.
[02] Martina Wetzel, Department of Geriatrics, Klinikum Braunschweig, Hannover Medical School, Braunschweig, Germany.
[03] Fabian Wetzel, Department of Radiotherapy and Radio-Oncology, Klinikum Braunschweig, Hannover Medical School, Braunschweig, Germany.
[04] Hans Christansen, Radiation Oncology, Hannover Medical School, Hannover, Germany.
[05] Wolfgang Hoffmann, Department of Radiotherapy and Radio-Oncology, Klinikum Braunschweig, Hannover Medical School, Braunschweig, Germany.
Abstract
Purpose: The aim of this analysis was to assess the hematological toxicity profile of glioblastoma patients undergoing radiation and temozolomide treatment (RCT). Methods: A total of 69 patients were evaluated retrospectively. A correlation analysis was undertaken to explore factors predisposing for acute hematological toxicity. Results: The overall incidence of any clinically acute hematologic toxicity was 42%. Severe anemia (i.e. grade 3/4), leucopenia and thromobocytopenia was diagnosed in 5.8%, 7.2% and 8.6% of the patients respectively. MGMT methylation was described in 23 (35%) cases. Female gender and MGMT methylation seemed to be risk factors for grade 4 toxicity (p< 0.05). The mean irradiated volume for patients with any degree of hematotoxicity was 238.4 ccm compared to 211.9 ccm for patients without any toxicity reactions. Conclusions: Our results confirmed that the female gender, radiation volume and MGMT methylation were factors associated with severe hematotoxicity. To our knowledge this is the first report suggesting the relevance of the MGMT methylation status of glioblastoma cells to treatment-related toxicity.
Keywords
Malignant Glioma, Temozolomide, Myelosuppression
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