[01] Bulbul-A-Munira , Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh. [02] Sadia Afreen Chowdhury, Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh.

The current study was aimed to investigate the antibacterial as well as neuropharmacological and analgesic activities of methanol extract from the leaf and bark of Garcinia cowa (Family: Clusiaceae). The antibacterial activity test was performed by determining the zone of inhibition of living microorganisms compared with the standard drug, Ciprofloxacin. The result showed that, the petrolium ether, dichloromethane and methanol extracts from the leaf and bark have mild to moderate antibacterial activity. The neuropharmacological screening was evaluated by hole cross and open field tests where a significant and dose dependent suppression of motor activity and exploratory behavior was observed in the methanol extract of G. cowa when treated in Swiss Albino mice with the reference sedative drug, Diazepam. The analgesic activity was evaluated by using acetic acid-induced writhing test and tail immersion method at a dose of 200 and 400 mg/kg body weight. The results displayed 40.68% and 52.31% of inhibition for leaf and 56.18% and 56.91% for bark extract in the acetic acid-induced writhing test which is mild to the reference standard drug, Diclofenac-Na whose writhing inhibition was 78.21%. The analgesic activity in the tail immersion method was dose dependent.

Garcinia cowa, Antibacterial Activity, Neuropharmacological Activity, Analgesic Activity, Ciprofloxacin, Diazepam, Diclofenac-Na

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