International Journal of Biomedical and Clinical Sciences
Articles Information
International Journal of Biomedical and Clinical Sciences, Vol.4, No.1, Mar. 2019, Pub. Date: Apr. 17, 2019
Linear B-cell Epitope in Mycobacterium tuberculosis Using a Similarity Index
Pages: 29-32 Views: 1343 Downloads: 256
Authors
[01] Raúl Isea, Fundación Instituto de Estudios Avanzados, Hoyo de la Puerta, Baruta, Venezuela.
[02] Karl Erik Lonngren, Department of Electrical and Computer Engineering, University of Iowa, Iowa City, USA.
Abstract
At the present time, almost one third of the human population resides in regions where one could contract Tuberculosis and the standard Bacille Calmette-Guerin (BCG) vaccine is not able to protect adults. For this reason, a new vaccine against this disease must be developed. This paper identifies all the known epitopes of B cells in order to assist in the development of such a new vaccine against this disease. In order to do that, the epitopes of the B cell present in the genome of M. tuberculosis will be presented using six different computer programs. To decrease the number of epitopes predicted computationally, a restriction based on using the Similarity Index will be imposed. With this limitation, the number of epitopes is reduced to 198 epitopes. Using this result, it should be possible to perform laboratory studies to validate each of these epitopes which would allow one to develop a more useful vaccine against tuberculosis.
Keywords
Tuberculosis, Similarity Index, B Epitope, Mycobacterium
References
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