International Journal of Biomedical and Clinical Sciences
Articles Information
International Journal of Biomedical and Clinical Sciences, Vol.5, No.2, Jun. 2020, Pub. Date: Apr. 7, 2020
Multifractal Segmentation Analysis of Optical Coherence Tomography Angiography Images for Normal and Diabetic Retinopathy Eyes
Pages: 75-86 Views: 82 Downloads: 39
Authors
[01] Gomaa El Damrawi, Glass Research Group, Physics Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
[02] Tarek Mohsen, Ophthalmology Canter, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
[03] Mohsen Zahran, Physics Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
[04] El Shaimaa Amin, Physics Department (biophysics), Faculty of Science, Mansoura University, Mansoura, Egypt.
Abstract
For normal subjects and diabetic patients, the purpose of this analysis is to measure the blood vascular network density of the retina in the superficial layer using OCTA image technique. Several techniques were applied to the images, such as box counting size, information dimension, lacunarity parameters, and multi-fractal analysis. There were small variations in fractal dimension of retinal vascular network between the images of normal subjects and diabetic patients. The main point of this research is the reliable anatomized segmentation of the vessel and the retinal vascular which analyzed as a multifractal object. The obtain images were then equally divided into several divided regions, with each area being evaluated as an image. The findings were consistent and help us to differentiate between ordinary and diabetes patients. The applied technique of practical analysis is used to describe and characterize images representing complex anatomical structures. However, the fractal dimension measurement as a key index is deeply based on the quality of the images obtained. Furthermore, the selected segmentation methods and the method for measuring the fractal dimension have been standardized.
Keywords
Blood Vascular Network, Optical Coherence Tomography Angiography, Box Counting, Multifractal
References
[01] De Barros Garcia, David Leonrdo Cruvinel Isaac and Marcos Avila, (2017). Diabetic retinopathy and OCT angiography: clinical findings and future perspectives, International Journal of Retina and Vitreous, 3: 14: 2-10.
[02] Crawford TN, Alfaro DV 3rd, Kerrison JB, Jablon EP (2009) Diabetic retinopathy and angiogenesis. Curr Diabetes Rev 5: 8-13.
[03] Ye Sun and Lois E. H. Smith, Retinal Vasculature in Development and Diseases, (2018) Annu Rev Vis Sci.; 4: 101-122.
[04] Kostic M, Bates NM, Milosevic NT, Tian J, Smiddy WE, Lee W-H, Somfai GM, Feuer WJ, Shiffman JC, Kuriyan AE, Gregori NZ, Pineda S and Cabrera DeBuc D (2018) Investigating the Fractal Dimension of the Foveal Microvasculature in Relation to the Morphology of the Foveal Avascular Zone and to the Macular Circulation in Patients With Type 2 Diabetes Mellitus. Front. Physiol. 9: 1233. doi: 10.3389/fphys. 012334.
[05] Natasa Popovic, Mirko Lipovac, Miroslav Radunovic, Jurgi Ugarte, Erik Isusquiza, Andoni Beristain, Ramón Moreno, Nerea Aranjuelo, Tomo Popovic. (2019) Fractal characterization of retinal microvascular network morphology during diabetic retinopathy progression. Wiley Microcirculation journal, b DOI: 10.1111/micc.12531.
[06] Jirarattanasopa P, Ooto S, Tsujikawa A, et al. (2012) Assessment of macular choroidal thickness by optical coherence tomography and angiographic changes in central serous chorioretinopathy. Ophthalmology; 119: 1666–1678.
[07] Ohno-Matsui K, Akiba M, Moriyama M, et al. (2012) Acquired optic nerve and peripapillary pits in pathologic myopia. Ophthalmology.; 119: 1685–1692.
[08] Vasilios Katsikis, Methods for Biomedical Images. In “MATLAB - A Fundamental Tool for Scientific Computing and Engineering Applications - Vol. 3 (ed.) (2012), chapter 7, pp. 161-178.
[09] Mandelbrot B. B. (1991) Fractals and the rebirth of experimental mathematics. Fractals for the classroom, by H. O. Peitgen, H. Jurgens, D. saupe, E. M. Matelski, T. perciante, L. E. Yunker. New York: Springer, 1991.
[10] Ştefan Ţălu, Sebastian Stach, Dan Mihai Călugăru, Carmen Alina Lupaşcu, Simona Delia Nicoară, (2017) Analysis of normal human retinal vascular network architecture using multifractal geometry, Int J Ophthalmol, Vol. 10, No. 3, Mar. 18.
[11] Azemin MZ, Kumar DK, Wong TY, Kawasaki R, Mitchell P, et al. (2011) Robust methodology for fractal analysis of the retinal vasculature. IEEE Trans Med Imaging 30: 243-250.
[12] Mandelbrot, B. B. (1982), The Fractal Geometry of Nature, New York, W. H. Freeman, 95–107.
[13] Gould DJ, Vadakkan TJ, Poché RA, Dickinson ME (2011) Multifractal and lacunarity analysis of microvascular morphology and remodeling. Microcirculation 18: 136-151.
[14] D. Easwaramoorthy, P. S. Eliahim Jeevaraj, A. Gowrisankar, A. Manimaran and S. Nandhini, (2018). Fuzzy Generalized Fractal Dimensions Using Inter-Heartbeat Dynamics in ECG Signals far Age-Related discrimination, International Journal of Engineering & Technology, 7 (4.10) 900-903.
[15] R. Uthayakumar and A. Gowrisankar (2014) Generalized Fractal Dimensions in Image Thresholding Technique. Information Sciences Letters an International Journal. Inf. Sci. Lett. 3, No. 3, 125-134.
[16] Stosic T, Stosic BD (2006) Multifractal analysis of human retinal vessels. IEEE Trans Med Imaging 25: 1101-1107.
[17] Barabási AL, Vicsek T (1990) Self-similarity of the loop structure of diffusion-limited aggregates. J Phys A: Math Gen 23: L729-L733.
[18] Lopes R., Betrouni N., (2009) Fractal and multifractal analysis: A review. Medical Image Analysis, 13: 634–649.
[19] Posadas AND, Giménez D, Quiroz R, Protz R (2003) Multifractal characterization of soil pore systems. Soil Sci Soc Am J 2003, 67: 1361-1369.
[20] Zahid S, Dolz-Marco R, Freund KB, et al. Fractal dimensional analysis of optical coherence tomography angiography in eyes with diabetic retinopathy. Invest Ophthalmol Vis Sci. 2016; 57: 4940– 4947. DOI: 10.1167/iovs.16-19656.
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