International Journal of Chemical and Biomolecular Science
Articles Information
International Journal of Chemical and Biomolecular Science, Vol.1, No.2, Aug. 2015, Pub. Date: Jul. 16, 2015
Bioinorganic and Pharmacological Study of Fe(II)-Coumarin Complex
Pages: 43-48 Views: 2069 Downloads: 1164
Authors
[01] Rakesh Choure, Department of Chemistry, Hari Singh Gour University, Sagar, India.
[02] Neelam Vaidya, Department of Chemistry, Hari Singh Gour University, Sagar, India.
Abstract
The formation of complexes of Coumarin and Fe(II) was studied in aqueous media at pH 8.2±0.1 by polarography and spectroscopy. The polarogram indicated formation of complexes between coumarin and Fe(II). Coumarin produces a well-defined direct current polarogram and differential pulse polarogram in 1M Ammonium tartrate (supporting electrolyte) at pH 8.2±0.1. The stoichiometry of the Fe(II)-Coumarin complex is 1:1. Anticoagulant studies on the drug and its metal complex have been performed in albino mice. Revealing the complex to be more potent in anticoagulation activity compared to the parent drug.
Keywords
Coumarin, DCP, DPP , Prothrombin Time, Iron Complex
References
[01] F. Floc’ h, F. Mauger, J R. Desmurs, coumarin in plants and fruits, 27: 32-37 2002.
[02] Gwynne., “P. Drug”, Discovery Development (5),50-55 2002.
[03] C. W. Tornoe, C. Christensen, M. J. Meldal, Org. Chem. 67,3057-3064 2002.
[04] H. R. Dharmaratne, W. M. Wanigasakera, E. Mata – Greenwood, J. M., Pezzoto, Planta Med. 64, 460-461 1998.
[05] H. X. Wang, Planta Med., 67, 669-672 2001.
[06] A. J. Vlietinck, T. De Bruyne, S. Apers, L. A. Pieters, Planta Med. 64, 97-109 1998.
[07] R. A. Katz, A. M. Skalka, Annu. Rev. Biochem. 63, 133-173 1994.
[08] B. Lake, Coumarin metabolism, toxicity, and carcinogenicity: relevance for human risk assessment, Food and Chemical Toxicology,37,423- 453 1999.
[09] G. Feuer, The metabolism & biological actions of coumarins, Progress in Medicinal Chem, 10, 85-158 1974.
[10] H. R. Dharmaratne, G. T. Tan, G. P. Marasinghe, J. M. Pezzuto, Planta Med., 68, 86-87 2002.
[11] Z. Q. Xu, T. R. Jenta, M.T. Flavin, Current Opinion for Drug Discovery & Development, 3,155-166 2000.
[12] K. H. Lee, S. L. Morris-Natschke, Pure Appl. Chem. 71, 53-57 1999.
[13] S. L. Born, P. E. Rodriguez, C. L. Eddy, & L. D. Lehman-McKeeman, Drug Metabolism and Disposition. 25, 1318-1323 1997.
[14] M. Vocanson, C. Goujon, G. Chabeau, M. Castelain, M., Floc’h, F. Valeyrie, Maliverney, C. Gard, A., & J. F. Nicolas, The skin allergenic properties of chemicals may depend on contaminants, Int Arch Allergy Immunol 140, 231-238 2006.
[15] A. J. Quick’s, Am. J. Clin. Pathol. 45,105 1966.
600 ATLANTIC AVE, BOSTON,
MA 02210, USA
+001-6179630233
AIS is an academia-oriented and non-commercial institute aiming at providing users with a way to quickly and easily get the academic and scientific information.
Copyright © 2014 - American Institute of Science except certain content provided by third parties.