International Journal of Chemical and Biomolecular Science
Articles Information
International Journal of Chemical and Biomolecular Science, Vol.1, No.2, Aug. 2015, Pub. Date: Jul. 16, 2015
Bioinorganic and Pharmacological Study of Fe(II)-Coumarin Complex
Pages: 43-48 Views: 2069 Downloads: 1164
[01] Rakesh Choure, Department of Chemistry, Hari Singh Gour University, Sagar, India.
[02] Neelam Vaidya, Department of Chemistry, Hari Singh Gour University, Sagar, India.
The formation of complexes of Coumarin and Fe(II) was studied in aqueous media at pH 8.2±0.1 by polarography and spectroscopy. The polarogram indicated formation of complexes between coumarin and Fe(II). Coumarin produces a well-defined direct current polarogram and differential pulse polarogram in 1M Ammonium tartrate (supporting electrolyte) at pH 8.2±0.1. The stoichiometry of the Fe(II)-Coumarin complex is 1:1. Anticoagulant studies on the drug and its metal complex have been performed in albino mice. Revealing the complex to be more potent in anticoagulation activity compared to the parent drug.
Coumarin, DCP, DPP , Prothrombin Time, Iron Complex
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