[01] Husni Abdulla Mhammad, Faculty of Science, University of Duhok, Duhok, Iraq. [02] Amad M. Saleh Jubrail, Faculty of Science, University of Duhok, Duhok, Iraq. [03] Malika Kassim Najeeb, Faculty of Science, University of Duhok, Duhok, Iraq.

The use of different plants and spices as herbal drugs for treating different diseases has been tested in many studies. Therefore, this study was designed to study the histological changes in liver, kidneys and spleen of male albino rats after treated with cinnamon extract in which, normal and diabetic rats were used. During this study, forty adult male rats weighting about 170-188g were randomly divided into four groups each with 10 rats; each group was designed as follows: The first group was used as a control and was fed on standard diet and tap water ad libitum. The second group was treated with alcoholic cinnamon extract (500 mg/kg.bw). Third group was group was injected with alloxan as a diabetic group. The fourth group was diabetic rats treated with alcoholic cinnamon extract (500 mg/kg. bw). After 30 days of experiment, rats were anaesthetized rats were anaesthetized and the blood was taken by cardiac puncture for estimation biochemical parameters and samples of liver, kidneys and spleen were fixed in formalin 10% and processed for histological studies. During histological examination of liver, kidney and spleen, no structural changes were found in the tissue of the examined organs in normal rats treated with cinnamon. In the diabetic group, structural damages were observed in the liver and kidneys whereas, spleen showed no obvious changes in all animals, these damages were reduced after administration of cinnamon extract to diabetic rats. Conclusion: From the results of the present study, it can be concluded that ethanolic extract of cassia cinnamon bark has improving role against abnormal histological changes in kidneys and liver of diabetic rats.

Cinnamon Extract, Diabetic Rats

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