International Journal of Chemical and Biomolecular Science
Articles Information
International Journal of Chemical and Biomolecular Science, Vol.2, No.1, Feb. 2016, Pub. Date: Jan. 6, 2016
Synthesis and Antimicrobial Activity of Some Substituted Cyclopentyl Phenols
Pages: 1-3 Views: 2068 Downloads: 757
[01] D. A. Pisanenko, Chemical Technologies of Organic Substances, National Technical University of Ukraine "Kyiv Polytechnic Institute", Kiev, Ukraine.
[02] Yu. L. Voljanskii, Mechnikov Institute of Microbiology and Immunology, Academy of Medical Sciences of Ukraine, Charkov, Ukraine.
Some substituted cyclopentyl phenols were synthesized and screened for possible antibacterial and antifungal activities against Staphylococcus aureus, Streptococcus viridans, Escherichia coli, Shigella flexneri, Salmonella typhi, Salmonella typhimurium, B.proteus vulgaris, Pseudomonas aeruginosa, Bacterium antracoides, Bacterium subtilis, Klebsiella rhinoscleuromatis and Candida albicans using the microdilution method. Antimicrobial tests results indicated that all compounds have reasonable activity. They displayed the highest antimicrobial activity against Streptococcus aureus and Streptococcus viridans. The cyclopentyl phenols containing aryl substituted cyclopentyl radicals were the most active in the series against all tested bacteria and fungi strains.
Substituted Cyclopentyl Phenols, Synthesis, Antibacterial Activity, Antifungal Activity
[01] J. M. Tedder, A. Nechvatal, A. H. Jubb. Basic organic chemistry. Part 5. Industrial Products. Wiley, London, 1975.
[02] Ullman,s Fine Chemicals.Wiley-VCH-2014, 3 Volume set, p. 174.
[03] V. А. Baraboi. The biological effects of plant phenolic compounds (in Russ.). Кiev, 1976.
[04] R.P. Pizzolitto, C.L. Barberis, J.S. Damboleno et al.// Journal of Chemistry. Volume 2015(2015), Article ID 547925.
[05] H.H.F. Koolen, F.M.A. da Silva, F.C. Gozzo et al.// Food Res.Intern.2013, V.51, iss.2, pp. 467-473.
[06] H.M.N. Igbal, G. Kyazze, J.C. Locke et al.// Green Chemistry.2015, V.17, pp. 3858-3869.
[07] A. Blazej, L. Suty. Rastlinne Fenolove Zluceniny (Phenolic compounds of plant origin). Bratislava, 1973.
[08] G. Schuurmann, A. O. Aptula, R. Kuhne et al.// Chem. Res. Toxicol. 2003, 16(8), pp. 974-987.
[09] Yu. A. Nikolaev, I. A. Borzenkov, M. V. Kalinin et al. // Appl. Biochem. Microbiol. (in Russ.) // 2010, 46(2), pp. 172-179.
[10] N. Kongkathip, K. Hasitapan, N. Pradidphol. // Curr. Med. Chem. 2006, 13(30), pp. 3663-3674.
[11] D. A. Pisanenko, G. K. Palii, V. G. Kruchkova et al. // Antibiotics (in Russ.). 1981, 84, pp. 447-450.
[12] D. M. Fielgate, D. Woodcock. // Pestic.Sci.1974, 5(6), pp. 709-719.
[13] US Pat.4311711. Biocidal compositions, publ. 19.01.1982; US Pat.6132770. Surfactans, publ. 17.10.2000.
[14] Us Pat.6132740A. Resorcinol derivaties, publ. 17.10.2000. US Pat. 6828460B2. Resorcinol derivaties, publ. 07.12.2004.
[15] A. R. Abdurasuleva, F. H. Shadieva. // Zh. Obz. Chem. (in Russ.). 1959, 29, pp. 4921-4923.
[16] V. G. Kruchkova, A. A. Grigorenko. D. A. Pisanenko. // Izv.vuzov, Khim. Khim. Tekh. (in Russ.). 1974, 17(7), pp. 1104-1106.
[17] D. A. Pisanenko, G. K. Palii, V. G. Kruchkova. // Khim. Farm. Zh. 2010, 44(8), pp. 22-24.
[18] D. A. Pisanenko, Yu. I. Smirnov-Zamkov. // Ukr.Khim.Zh. 2001, 67(10), pp. 102-105.
[19] D. A. Pisanenko, Yu. I. Smirnov-Zamkov. // ibid.2004, 70(2), pp. 113-118.
[20] D. A. Pisanenko, A. A. Grigorenko, G. K. Palii. // Khim. Farm. Zh. 2000, 34(12), pp. 17-18.
MA 02210, USA
AIS is an academia-oriented and non-commercial institute aiming at providing users with a way to quickly and easily get the academic and scientific information.
Copyright © 2014 - American Institute of Science except certain content provided by third parties.