[01] Veyan Taher Seleman, Chemistry Department, Faculty of Science, University of Duhok, Duhok, Iraq. [02] Vian Yamin Jarjes, Chemistry Department, Faculty of Science, University of Duhok, Duhok, Iraq. [03] Marwan Khalil Qader, Biology Department, Faculty of Science, University of Duhok, Duhok, Iraq.

Synthesis, characterization, and biological activity of a new (cysteine) complexes, the complex are consistent with the formula [M₂ClSn (C₆H₁₂N₂O₄S₂)₂]. The IR spectroscopy show coordination of the ligand to M(II) through four N atoms in a square planar geometry. The dinuclear complexes of Mn⁺² Co⁺², Ni⁺², Cu⁺² and Zn⁺² were prepared by the reaction of the above ligands with the metal chloride in (1:2) metal to ligands ratio. The ligands and their complexes have been characterized by their analytical, spectral data, conductivity and magnetic measurements. Electronic spectra and magnetic measurements indicates that the dinuclear have square planar geometry. Final solutions of the complex against Bacterial and Fungicides showed a pronounced activity of the complex even at low concentrations at 10-3 m in ethanol solvent. The antibacterial activities of synthesized compounds were studied against Gram-negative pathogen bacterial species (Gram-negative species Pseudomonas areugenosa, Escherichia coli and Klebsiella pneumonia. Gram positive species Staphylococcus aureus and Streptococcus pyogenes. The antifungal activity of synthesized compounds were studied against some species of Candida C. tropicalis, C. albicanus, C. dublicans, C. krusei and C. glabrata using the disc diffusion method. The results showed that all complexes exhibited prominent antimicrobial activity against the tested isolates measuring inhibition zones at several values in mm.

Cysteine, Ligands, Antifungal, Antibacterial

[01] Nagham S. Buttrus, (2014). Synthesis and Characterization of some Cr⁺³, Fe⁺³, Co⁺², Ni⁺², Cu⁺² and Zn⁺² Complexes with N-Phthalyl amino acid ligands research Journal of Chemical Science Vol 4(5), 41-47. [02] Nicholas J. Pace and Eranthie Weerapana Biomolecules (2014) 4, 419-434. [03] Andreini, C.; Banci, L.; Bertini, I.; Rosato, A. (2006). Counting the zinc-proteins encoded in the human genome. J. Proteome Res. 5(13): 196–201. [04] Lee, Y.-M.; Lim, C. (2008). Physical basis of structural and catalytic Zn-binding sites in proteins. J. Mol. Biol. 379, 545–553. [05] Franklin RC, Matthew AW, Jeff A, Michael ND, George ME, Mary JF, Dwight JH, David WH, Janet AH, Jean BP, Mair P, Jana MS, Richard BT, Maria MT, John DT, Melvin PW, Barbara LZ (2012). National Committee for Clinical Laboratory Standards, 32(1): 45-48. [06] Wilson CL, Solar JM, El Ghaouth A, Wisniewski ME (1997). Rapid evaluation of plant extracts and essential oils for antifungal activity against Botrytis cinerea. Plant Dis., 81:204-210. [07] Zhu XF, Zhang HX, Lo R (2005). Antifungal activity of Cynara scolymus L. extracts. Fitoterapia, 76: 108-111. [08] Nostro A, Germano MP, Angeio VD, Marino A, Cannatell MA (2000). Extraction methods and bioautgraphy for evaluation of medicinal plant antimicrobial activity. Lett. Appl. Microbiol., 30: 379-384. [09] Loimaranta V, Jakubovics NS, Hytönen J, Finne J, Jenkinson HF, Strömberg N. Fluid- or surface-phase human salivary scavenger protein gp-340 express different bacterial recognition properties. Infect Immun. 2005;73:2245-2252. [10] Saharkhiz, M.J.; Motamedi, M.; Zomorodian, K.; Pakshir, K.; Miri, R.; Hemyari, K. Chemical composition, antifungal and antibiofilm activities of the essential oil of Mentha. piperita L. ISRN Pharm. 2012, 2012, 1–6. [11] Surbhi Leekha, MBBS; Christine L. Terrell, MD; and Randall S. Edson, MD (2011). General Principles of Antimicrobial Therapy, Mayo Clin Proc. ;86(2): 156-167. [12] Mandell LA, Wunderink RG, Anzueto A, et al. (2007). Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis.;44(suppl 2):S27-S72. [13] Pepin J, Saheb N, Coulombe MA, et al. (2005). Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec. Clin Infect Dis.;41(9):1254-1260.