[01] Wafaa M. Hikal, Department of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia; Parasitology Lab., Water Pollution Researches Department, National Research Center, Dokki, Giza, Egypt. [02] Hussein A. H. Said-Al Ahl, Medicinal and Aromatic Plants Researches Department, National Research Centre, Dokki, Giza, Egypt.

Through this work shed light on the importance of medicinal plants and natural products, which are important sources of biologically active substances of medical interest? And especially shed light on Hyssopous officinalis. Nevertheless, several experimental studies are required to confirm the therapeutic potential of this plant and determine whether biological differences reflect the different isolation procedures, different types of plant material used, phytochemical constituents or different chemotypes.

Hyssopous officinalis, Medicinal Plants, Anti-leishmanial Activity

[01] Lawless J (2002). The Encyclopedia of Essential Oils. Thorsons, 110-11. [02] Wesolowska A, Jadczak D, Grzeszczuk M (2010). Essential oil composition of hyssop (Hyssopus officinalis L.) cultivated in north-western Poland. Herba Polonica, 56 (1): 57-65. [03] Kizil S, Toncer O, Ipek A, Arslan N, Saglam S, Khawar KM (2008). Blooming stages of Turkish hyssop (Hyssopus officinalis L.) affect essential oil composition. Acta Agriculturae Scandinavica, Section B-Soil & Plant Science, 58(3): 273-279. [04] Kreis W, Kaplan MH, Freeman J, Sun DK, Sarin PS (1990). Inhibition of HIV replication by Hyssopus officinalis extracts. Antiviral Research, 14: 323-337. [05] Gollapudi S, Sharma HA, Aggarwal S, Byers LD, Ensley HE, Gupta S (1995). Isolation of a previously unidentified polysaccharide (MAR-10) from Hyssopus officinalis that exhibits strong activity against human immunodeficiency virus type 1. Biochemical and Biophysical Research Communications, 210: 145-151. [06] Letessier MP, Svoboda KP, Walters DR (2001). Antifungal activity of the essential oil of hyssop (Hyssopus officinalis). J. Phytopathology, (149): 673-8. [07] Ozer H, Sokmen M, Gulluce M, Adiguzel A, Kilic H, Sahin F, Sokmen, A, Baris O (2006). In vitro antimicrobial and antioxidant activities of the essential oils and methanol extracts of Hyssopus officinalis L. SSP. Angustifolius. Ital. J. Food Sci., (18): 73-83. [08] Grzeszczuk M, Jadczak D (2009). The estimation of biological value of some species of spice herbs. Acta Horticult., (830): 681-6. [09] Kermanjani A, Jalalizadegan B, Tabatabaie F (2015). Comparison of Hyssopus officinalis, Tussilage farfara, Carum copticumextracts versus systemic glucantime in the treatment of Cutaneous leishmaniasis in Balb/c Mice. Advanced Studies in Biology, 7 (2): 49-54. [10] Koudou J, Abena AA, Ngaissona P, Bessiere JM (2005). Chemical composition and pharmacological activity of essential oil of Canarium schweinfurthii. Fitoterapia, 76: 700-703. [11] Loizzoa MR, Saabb A, Tundisa R, Stattia GA, Lamprontic I, Menichinia F, Gambarid R, Cinatle J, Doer HW (2008). Phytochemical analysis and in vitro evaluation of the biological activity against herpes simplex virus type 1 (HSV-1) of Cedruslibani A. Rich. Phytomedicine, 15: 79-83. [12] M’Barek LA, Ait Mouse H, Jaafari A, Aboufatima R, Benharref A, Kamal M, Benard J, El Abbadi N, Ben salah M, Gamouh A (2007). Cytotoxic effect of essential oil of thyme (Thymus broussonettii) on the IGR-OV1 tumor cells resistant to chemotherapy. Braz. J. Med. Biol. Res., 40: 1537-1544. [13] Zarai Z, Kadri A, Chobba IB, Mansour RB, Bekir A, Mejdoub H, Gharsallah N (2011). The in-vitro evaluation of antibacterial, antifungal and cytotoxic properties of Marrubium vulgare L. Essential oil grown in Tunisia. Lipids Health Dis., 10: 161. [14] Alviano DS, Alviano CS (2009). Plant extracts: Search for new alternatives to treat microbial diseases. Curr. Pharm. Biotechnol., 10: 106-121. [15] Mazzant G, Battinelli L, Salvator G (1998). Antibacterial properties of the linalool rich essential oil of Hyssopous officinalis L. var. decumbens (Lamiaceae). FlavourFrag. J., 13: 298. [16] da Silva AR, Lopes PM, de Azevedo MB, Costa DM, Alviano CS, Alviano DS (2012). Biological activities of α-pinene and β-pineneenantiomers. Molecules, 17: 6305-6316. [17] Tabanca N, Demirci B, Crockett SL, Baser KHC, Wedge DE (2007). Chemical composition and antifungal activity of Arnica longifolia, Aster hesperius, and Chrysothamnus nauseosus essential oils. J. Agric. Food Chem., 55: 8430-8435. [18] Yang Z, Wu N, Zu Y, Fu Y (2011). Comparative anti infectious bronchitis virus (IBV) activity of (−)-pinene: Effect on nucleocapsid (N) protein. Molecules, 16: 1044–1054. [19] Garg SN, Naqvi A, Singh A, Ram A, Kumar S (1999). Composition of essential oil from an annual crop of Hyssopus officinalis grown in Indian plains. Flavour Frag. J., 14: 170-172. [20] De Martino L, De Feo V, Nazzaro F (2009). Chemical composition and in vitro antimicrobial and mutagenic activities of seven Lamiaceae essential oils. Molecules, 14: 4213-4230. [21] Svoboda KP, Galambosi B, Deans SG, Hethelyi E (1993). Agronomical and biochemical investigation of Hyssopus officinalis L. from various geographical sources. Acta Hort. 344: 434-443. [22] Veres K, Varga E, Dobos A, Hajdn Z, Mathe I, Pluhar Z, Nemeth, E, Bernath J (1997). Investigation of the composition of essential oils of Hyssopus officinalis L. populations, 217-220 pp. In: Ch. Franz, A. Mathe, G. Buchbaner (Eds), Essential Oils: Basic and Applied Research, Allured Publishing Corporation, Carol Stream, IL, pp. 217-220. [23] Vallejo M, Herraiz J, Perez-Alonso M, Velasco Negueruela A (1995). Volatile oil of Hyssopus officinalis L. from Spain. J. Essent. Oil Res. 7: 567-568. [24] Jankovsky M, Land T (2002). Genus Hyssopus L.-Recent Knowledge. Hort. Sci., (Parague) 29: 119-123. [25] Mitic V, Dordevic S (2000). Essential oil composition of Hyssopus officinalis L. cultivated in Serbia. Facta Universitatis, Physics Chemistry and Technology, 2: 105-108. [26] Gorunovic M, Bogavac P, Chalchat J, Chabardi J (1995). Essential oil of Hyssopus officinalis L. Lamiaceae of Montenegro origin. J. Essent. Oil Res., 7: 39-43. [27] Wang N, Yang XW (2010). Two new flavonoid glycosides from the whole herbs of Hyssopus officinalis. J. Asian Natural. Prod. Res., 12:1044-1050. [28] Said-Al Ahl HAH, Abbas ZK., Sabra AS., Tkachenko KG (2015). Essential oil composition of Hyssopus officinalis L. cultivated in Egypt. International Journal of Plant Science and Ecology, 1(2): 49-53. [29] Marin FR, Ortuño A, Benavente-Garcia O, Del Rio JA (1998). Distribution of flavone glycoside diosmin in Hyssopus officinalis plants: Changes during growth. Planta Med., 64: 181-182. [30] Marino M, Bersani C, Comi G (2001). Impedance measurements to study the antimicrobial activity of essential oils from Lamiaceae and compositae. Int. J. Food Microbiol., 67: 187–195. [31] Hilal SH, El-Alfy TS, El-Sherei MM (1979). Study of the flavonoid content of Hyssopus officinalis L. Egyptian J. Pharm. Sci., 20: 271-278. [32] Murakami Y, Omoto T, Asai I, Shimomura K, Yoshihira K, Ishimaru K (1998). Rosmarinic acid and related phenolics in transformed root cultures of Hyssopus officinalis. Plant Cell, Tissue and Organ Culture, 53: 75-78. [33] Varga E, Hajdu Z, Veres K, Mathe I, Nemeth E, Pluhar Z, Bernath J (1998a). Investigation of variation of the production of biological and chemical compounds of Hyssopus officinalis L. Acta. Pharm. Hung., 68: 183-188. [34] Kochan E, Wysokinska H, Chmiel A, Grabias B (1999). Rosmarinic acid and other phenolic acids in hairy roots of Hyssopus officinalis. Biosciences, 54: 11-16. [35] Zgorka G, Głowniak K (2001). Variation of free phenolic acids in medicinal plants belonging to the Lamiaceae family. J. Pharm. Biomed. Analysis, 26: 79-87. [36] Benedec D, Oniga I, Tipercius B, Popescu H (2002). Preliminary research of some polyphenolic compounds from Hyssopus officinalis L. (Lamiaceae). Farmacia, 50: 54-57. [37] Proestos C, Chorianopoulos N, Nychas GJ, Komaitis EM (2005). RPHPL Canalysis of the phenolic compounds of plant extracts. Investigation of their antioxidant capacity and antimicrobial activity. J. Agric. Food Chem., 53: 1190-1195. [38] Recio MC, Giner RM, Manez S, Rios JL (1995), Structural requirements for the anti-inflammatory activity of natural triterpenoids. Planta Med., 61: 182-185. [39] Cantrell CL, Franzblau SG, Fischer NH (2001), Antimycobacterial plant terpenoids. Planta Med., 67: 685-694. [40] Ohigashi H, Takamura H, Koshimizu K, Tokuda H, Ito Y (1986). Search for possible antitumor pro moters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation, ursolic acid and oleanolic acid from an anti-inflammatory Chinese medicinal plant, Glechoma hederacea L. Cancer Lett., 30, 143-151. [41] Rios MR, Gonzales-Morales A, Villarreal ML (2001), Sterols, triterpenes, bioflavonoids of Viburnum jucundum, and cytotoxic activity of ursolic acid. Planta Med., 67: 683-684. [42] Macato SB, Sucharita S (1997), Advances in triterpenoid research 1990-1994. Phytochemistry, 44: 1185-1236. [43] Tokuda H, Onigashi H, Koshimizu H (1986). Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Lett., 33, 279-285. [44] Liu J (1995), Pharmacology of oleanolic acid and ursolic acid. J. Ethnopharmacology 49, 57-68. [45] Skrzypek Z, Wysokinska H (2003). Sterols and triterpenes in cell Culture of Hyssopus officinalis L. Z. Naturforsch., 58c, 308-312. [46] Ali N, Mekuria AH, Requena JM, Engwerda C (2012). Immunity to visceral leishmaniasis, J. Trop. Med., (2012):780-809. [47] World Health Organization (2010). Control of the leishmaniases. Geneva: World Health Organization; 2010. [48] Alvar J, Vélez ID, Bern C, Herrero M, Desjeux P, Cano J, den Boer M (2012). Leishmaniasis worldwide and global estimates of its incidence. PLoS One, 7 (5): e35671. [49] Arevalo J, Ramirez L, Adaui V, Zimic M, Tulliano G, Miranda-Verástegui C, Lazo M, Loayza-Muro R, De Doncker S, Maurer A, Chappuis F, Dujardin JC, Llanos-Cuentas A (2007). Influence of Leishmania (Viannia) species on the response to antimonial treatment in patients with American tegumentary leishmaniasis. J. Infect Dis., 195 (12): 1846–1851. [50] Accioly MP, Bevilaqua CM, Rondon FC, de Morais SM, Machado LK, Almeida CA, de Andrade HFJ, Cardoso RP (2012). Leishmanicidal activity in vitro of Musa paradisiaca L. and Spondia smombin L. fractions. Vet. Parasitol., 187 (1–2): 79–84. [51] Date A, Joshi MD, Patravale VB (2007). Parasitic diseases: liposomes and polymeric nanoparticles versus lipid nanoparticles, Adv. Drug Deliv. Rev., 59 (6): 505–521. [52] Corral MJ, Benito-Peña E, Jiménez-Antón MD, Cuevas L, Moreno-Bondi MC, Alunda JM (2016). Allicin induces calcium and mitochondrial dysregulation causing necrotic death in leishmania, PLoSNegl. Trop. Dis., 10 (3): e0004525. [53] Markel L, Voge M (2006). Medical Parasitology, Edn 9, Saunders Elsevier Press, USA. [54] Hepburn NC (2001). Management of cutaneous leishmaniasis. Curr. Opin. Infect Dis., 14(2):151-154. [55] Akhlaghi L, Yeganeh M, Maleki F, Golestani M, Noori M, Ghelman M, Tabatabaie F (2014). Anti-leishmanial activity of Hyssopus officinalis, Tussilage farfara, Carum copticum extracts in mice infected with Leishmania major. International Journal of Herbal Medicine, 2(2): 142-145. [56] Iwu MM, Jackson JE, Schuster BG (1994). Medicinal plants in the fight against leishmaniasis. Parasitol. Today, 10:65. [57] Lerner EA, Grevelink SA (1996). Leishmaniasis. In: Arndt KA, Leboil PE, Robinson JK, editors. Cutaneous medicine and surgery. Philadelphia: W. B. Saunders, 1163-70. [58] Maleki F, Zarebavani M, Mohebali M, Dayer S, Hajialiani F, Tabatabaie F (2017). In vitro and in vivo susceptibility of Leishmania major to some medicinal plants. Asian Pacific Journal of Tropical Biomedicine, 7 (1): 37–42. [59] Rosa MdS, Mendonça-Filho RR, Bizzo HR, Rodrigues Id, Maria R, Soares A, Souto-Padrón T, Alviano CS, Lopes AHCS (2003). Antileishmanial activity of a linalool-rich essential oil from Croton cajucara. Antimicrob. Agents Chemother., 47 (6): 1895-1901 [60] Alexander J, Satoskar AR, Russel DG (1999). Leishmania species: models of intracellular parasitism. J. Cell Sci., 112: 2993-3002. [61] Hall LR, Titus RG (1995). Sand fly saliva selectively modulates macrophage functions that inhibit killing of Leishmania major and nitric oxide production. J. Immunol., 155:3501-3506. [62] Liew FY, O'Donnel CA (1993). Immunology of leishmaniasis. Adv. Parasitol., 32:161-259. [63] Desjeux P (1991). Information on the epidemiology and control of the leishmaniases by country and territory. Report no. 27. World Health Organization, Geneva, Switzerland. [64] Lopes AHCS, Dutra PML, Rodrigues CO, Soares MJ, Angluster J, Cordeiro RSB (1997). Effect of platelet-activating factor on the process of cellular differentiation of Herpetomonasmu scarum. J. Eukaryot. Microbiol., 44:321-325. [65] Alvar J, Cañavate C, Gutiérrez-Solar B, Jiménez M, Laguna F, López-Vélez R, Molina R, Moreno J (1997). Leishmania and human immunodeficiency virus co-infection: the first 10 years. Clin. Microbiol. Rev., 10:298-319. [66] Olliaro PL, Bryceson ADM (1993). Practical progress and new drugs for changing patterns of leishmaniasis. Parasitol. Today, 9:323-328. [67] Fournet A, Hocquemiller R, Roblot F, Cavé A, Richomme P, Bruneton J (1993). Les chimanines, nouvellesquinoléinessubstituées en 2 isoléesd′uneplantebolivienneantiparasitaire: Galipea longiflora. J. Nat. Prod., 56:1547-1552. [68] Fournet A, Hocquemiller R, Gantier JC (1995). Combattre la leishmaniose. Recherche, 26:424-429. [69] Croft SL, Yardley V (2002). Chemotherapy of leishmaniasis. Curr. Pharm. Des., 8:319-342. [70] Rates SMK (2001). Plants as source of drugs. Toxicon, 39:603-613.