International Journal of Materials Chemistry and Physics
Articles Information
International Journal of Materials Chemistry and Physics, Vol.6, No.3, Sep. 2020, Pub. Date: Nov. 23, 2020
Bactericidal and Toxicidal Activity of Metal Peroxo Complexes of Thorium (IV) Synthesizing with Organic Acids and Amine Bases
Pages: 43-48 Views: 506 Downloads: 139
[01] Jahanara Nasrin, Department of Materials Science and Engineering, University of Rajshahi, Rajshahi, Bangladesh.
Peroxo metal complexes have an important place within the medicinal inorganic chemistry since they exhibit different oxidation states and can interact with a number of negatively charged molecules. This activity of transition metals led to the recent development to of drugs which are based on metals and are considered to be potential candidates for pharmacological and the rapeutic applications. Both the ligand and the metal complexes of Th(IV) were screened for their antibacterial activity against Pseudomonas aeruginosa, Sarcina lutea, Streptococcus bodyii, Streptococcus--haemolyticus. Escherichia coli, Bacillus megaterium, B. subtilis, Shigella sonnei, S.flexneri, S.dysenteriae, S.bodyii and S.shiga. The toxicidal activity of the ligand and its complexes against the brine shrimp was also investigated. The screening results revealed that the compound K[ThO(O2)(ala)(4-pic)] has a strong inhibition and active antimicrobial activities against the bacteria compared to other compound tested. Results also showed that the lethal toxicity of peroxo complexes of metal Th(IV) varied significantly against the mortality of brine shrimp at different exposure periods. The complex K[ThO(O2)(gly)(2-pic)] was found to be more toxic against the mortality brine shrimp indicating the lower values of 8.49 and 203.8g/mL lethal concentration for 50 (LC99) and 99% (LC99) respectively at both exposures of 36-h.
Peroxo Complexes, Bactericidal Activity, Cytotoxicity, Lethal Toxicity, Microbial Activity
[01] Amah, C., Ondoh, A. M., Yufanyi, D. M., and Gaelle, D. S. Y., (2015). “Synthesis, crystal structure and antimicrobial properties of an anhydrous copper(ii)complex of pyridine-2-carboxylic acid”, Int. J. Chem., 7, 10–20.
[02] Silva, P. P., Guerra, W., Silveira, J. N., Ferreira, A. M. D. C., Bortolotto, T., Fischer, F. L., and Terenzi, H., (2011). “Two new ternary complexes of Copper (II) with tetracycline or doxycycline and 1,10-phenanthroline and their potential as antitumoral: cytotoxicity and DNA cleavage”, Inorg. Chem., 50, 6414–6424.
[03] Spellberg, B., Guidos, R., Gilbert, D., Bradley, J., Boucher, H. W., Scheld, W. M., (2008). “The epidemic of antibiotic-resistant infections: A call to action for the medical community from the in factious diseases society of America”, Clinical Infec. Disea.”, 46, 155–164.
[04] Wang, Q., Huang, M., Huang, Y., Zhang, J.-S., Zhou, G.-F., Zeng, R.-Q., and Yang, X.-B., (2014). “Synthesis, characterization, DNA interaction, and antitumor activities of mixed-ligand metal complexes of kaempferol and 1,10-phenanthroline/2,2′-bipyridine”, Med. Chem. Res., 23, 2659–2666.
[05] Shaabani, B., Khandar, A. A., Dusek, M., Pojarova, M., and Mahmoudi, F., (2013). “Synthesis, crystal structure, antimicrobial activity and electrochemistry study of chromium (III) andcopper (II) complexes based on semicarbazone Schiff base and azide ligands”, Inorg. Chim. Acta, 394, 563–568.
[06] Haque, M. M., Kudrat-E-Zahan, M., Banu, L. A., Islam, M. S., and Islam, M. S., (2015). “Synthesis and characterization with antineoplastic, bio-chemical, cytotoxic and antimicrobial studies of Schiff base Cu(II) ion complexes”, Bioinorg. Chem. Appl.
[07] Kudrat-E-Zahan, M., and Islam, M. S., (2015). “Synthesis, characterization and antimicrobial activity of some metal complexes of Cu(II), Ni(II), Zn(II), Pb(II), Co(II), Mn(II) and U(VI) containing bidentate Schiff base of [S-methyl-3-(4-methoxy benzylidine) dithiocarbazate]”, Rus. J. gen. Chem., 85(4), 979-983.
[08] Fricker, S. P., (1999). “A screening strategy for metal antitumor agents as exemplified by Gold(III) complexes”, Metal-Based Drugs., 6, 291-300.
[09] Hall, M. D., Dolman, R. C., and Hambley, T. W., (2004). In Metal Complexes in Tumor Diagnosis and as Anticancer Agents, Metal ions in Biological Systems, ed. A. Sigel and H. Sigel, Marcel Dekker, Inc., NewYork & Basel, vol.24, 297-322.
[10] Bednarski, P. J., Grunert, R., Zielzki, M., Wellner, A., Mackay, F. S., and Sadler, P. J., (2006). “Light activated destruction of cancer cell nuclei by platinum diazide complexes”, Chem. Biol., 13, 61-67.
[11] Olar, R., Badea, M., Carp, O., Marinescu, D., Lazar, V., Balotescu, C., and Dumbrava, A., (2008). “Synthesis, characterisation and thermal behaviour of some thiosulfato-and sulfato copper(II) complexes-Antibacterial activity”, J. Therm. Anal. Calorim., 92(1), 245-251.
[12] Tavman, A., Boz, I., Birteksoz, A. S., Cinarli, A., (2010). “Spectral characterization and antimicrobial activity of Cu(II) and Fe(III) complexes of 2-(5-Cl/NO2-1H-benzimidazol-2-yl)-4-Br/NO2-phenols”, J. Coord. Chem., 63, 1398-1410.
[13] Tapiero, H., Townsend, T. M., and Tew, K. D., (2003). “Trace elements in human physiology and pathology”, Copper Review. Biomed. Pharm., 57, 386-398.
[14] Arnal, N., Cristalli, D. O., deAlaniz, M. J. T., and Marra, C. A., (2010). “Clinical utility of copper, ceruloplasmin, and metallo thione in plasma determinations in human neuro degenerative patients and their first-degree relatives”, Brain Res., 1319, 118-130.
[15] Jimenez-Garido, N., Perello, L., Ortiz, R., Alzuet, G., Gonzalez-Alvarez, M., Canton, E., Liu-Gonzalez, M., Garcia-Granda, S., and Perez-Priede, M., (2005). “Antibacterial studies, DNA oxidative cleavage, and crystal structures of Cu(II) and Co(II) complexes with two quinolone family members, cipro floxacin andenoxacin”, J. Inorg. Biochem., 99, 677-689.
[16] Reichling, J., Koch, C., Stahl-Biskup, E., Sojka, C., and Schnitzler, P., (2005). “Virucidal activity of a beta-triketone-rich essential oil of Leptospermum scoparium (manuka oil) against HSV-1 and HSV-2 in cell culture”, Planta Med., 71, 1123–1127.
[17] Ozcankaya, R., and Delibas, N., (2002). “Malon dialdehyde, super oxide dismutase, melatonin, iron, copper, and zinc concentrations in patients with Alzheimer disease: cross-sectional study”, Croat. Med. J., 43, 28–32.
[18] Rosu, T., Pahontu, E., Pasculescu, S., Georgescu, R., Stanica, N., Curaj, A., Popescu, A., and Leabu, M., (2010). “Synthesis, characterization antibacterial and anti proliferative activity of novel Cu (II) and Pd(II) complexes with 2- hydroxy-8-R-tricyclo [,7)] tridecane-13-on ethio semi carbazone”, Eur. J. Med. Chem., 45, 1627-1634.
[19] Parmar, S., and Kumar, Y., (2009). “Synthesis, spectroscopic, and antimicrobial studies of the bivalent Nickel, and Copper complexes of Thiosemicarbazide”, Chem. Pharm. Bull. 57, 603-606.
[20] Nasrin, J., (2015). “Comparative studies on the metallurgical and biological activity of peroxo complexes of molybdenum (VI) and uranium (VI)”, Intl. J. Materials Sci. & Applic., 4, 26-30.
[21] Nasrin, J., (2007). ”Synthesis, structural characterization and biological activity of peroxo complexes of Zirconium (IV) containing organic acid and amine bases”, J. Appl. Sci., 7(3), 434-441.
[22] Singh, V. P., and Katiyar, A., (2008). “Synthesis, spectral characterization and antimicrobial activity of some transition metal (II) complexes with acetone pamino acetophenone benzoyl hydrazone”, Pestic. Biochem. Phys., 92, 8-14.
[23] Kachadourian, R., Brechbuhl, H. M., Ruiz-Azuara, L., Gracia-Mora, I., and Day, B. J., (2010). “Casio peinaII gly induce d oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells”, Toxicology, 268, 176-83.
[24] Alemon-Medina R., Brena-Valle, M., Munoz-Sanchez, J. L., Gracia-Mora M. I. and Ruiz-Azuara, L., (2007). “Induction of oxidative damage by copper-based antineo plastic drugs (Casio peinas R)”, Cancer Chemother. Pharmacol., 60, 219-228.
[25] Arora, K., Srivastava, A. K., and Chauhan, A. S., (2015). “Some new Thorium(IV) complexes of azoester ligands (Part-II)”, Oriental J. Chem., 31, 147-155.
[26] Khoo, T. J., bin Break, M. K., Crouse, K. A., Tahir, M. I. M., Ali, A. M., et al., (2014). “Synthesis, characterization and biological activity of two Schiff base ligands and the irnickel (II), copper (II), zinc (II) and cadmium (II) complexes derived from S-4-picolyldithio carbazate and X-ray crystal structure of cadmium (II) complex derived from pyridine-2-carboxalde hyde”, Inorg. Chim. Acta, 413, 68-76.
[27] Keypour, H., Shooshtari, A., Rezaeivala, M., Kup, F. O., and Rudbari, H. A. (2015). “Synthesis of two new N2O4 macroacyclic Schiff base ligands and their mononuclear complexes: Spectral, X-ray crystal structural, antibacterial and DNA cleavage activity”, Polyhedron, 97, 75-82.
[28] Chandra, S., and Vandana, K. S., (2015). “Synthesis, spectroscopic, anticancer, antibacterial and antifungal studies of Ni(II) and Cu(II) complexes with hydrazine carboxamide, 2-[3-methyl-2-thienyl methylene]”, Spectrochim Acta A Mol. Biomol . Spectrosc, 135, 356-363.
[29] Tachakittirungrod, S., Okonogi, S., Chowwanapoon-pohn, S., (2007). “Study on antioxidant activity of certain plants in Thailand: mechanism of antioxidant action of guava leaf extract”, Food Chem., 103, 381–388.
[30] Akila, E., Usharani, M., and Rajavel, R. (2013). “Metal(II) complexes of bioinorganic and medicinal relevance: antibacterial, antioxidant and DNA cleavage studies of tetradentate complexes involving O,N-donor environment to f3,3′-dihydroxy benzidine-based Schiff bases”, Int. J. Pharm. Sci., 5, 573–581.
[31] Yu, Y. Y., Xian, H. D., Liu, J. F., and Zhao, G. L., (2009). “Synthesis, characterization, crystal structure and antibacterial activities of transition metal (II) complexes of the schiff base 2-[(4-methyl phenylimino) methyl] -6-methoxyphenol”, Molecules, 14, 1747–1754.
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