Journal of Nanoscience and Nanoengineering
Articles Information
Journal of Nanoscience and Nanoengineering, Vol.1, No.4, Dec. 2015, Pub. Date: Sep. 26, 2015
The Characterization and Effectiveness Penetrasion of Caffeine Trapped and Coated Chitosan Nanoparticles as Anti-Cellulite
Pages: 198-205 Views: 1030 Downloads: 979
Authors
[01] Pipih Suptijah, Departement Aquatic Produc Technology, Faculty Fiosheries and Marine Science Bogor Agricultural University, West Java, Indonesia.
[02] Joshita Djajadisastra, Faculty Pharmacy, University of Indonesia, Depok, Indonesia.
[03] Candra Kirana Hartuti Saputro, Departement Aquatic Produc Technology, Faculty Fiosheries and Marine Science Bogor Agricultural University, West Java, Indonesia.
[04] Taufik Hidayat, Departement Aquatic Produc Technology, Faculty Fiosheries and Marine Science Bogor Agricultural University, West Java, Indonesia.
Abstract
Chitosan used as drug carrier because of is natural polycationic and easily modified in chemical and physical properties. In this research chitosan was chemically modified by coating and entrapping anti-cellulite active substance of caffeine and physically modified by minimizing chitosan particle size into nanoparticles size. The purpose of this research were to characterize the chitosan nanoparticles from its morphology, particle size, function of group, the value of adsorption efficiency, and effectiveness of chitosan nanoparticles against In Vitro penetration of caffeine as anti-cellulite using Franz diffusion cell. The morphology characterization test of caffeine trapped in chitosan nanoparticles and caffeine coated by chitosan nanoparticles resulting a smooth surface, slight convex shape, and agglomerated particles; average size of particles are 232.74 nm and 226.62 nm respectively; the function group showed a shift of wave number of amide III groups (-CN) and hydroxyl groups (-OH); the caffeine adsorption efficiency are 51.35% and 64.63% respectively. The result of effective penetration were 1.089.65 ± 10.7 µg/cm2 and 2.170.03 ± 6.85 µg/cm2 respectively.
Keywords
Anti-Cellulite, Caffeine, Chitosan, Chitosan Nanoparticles
References
[01] Ansel H, LV Allen, NG Popovich 1999. Pharmaceutical Dosage Forms and Drug Systems 7th edition. Maryland: Lippincot Williams and Willkins.
[02] Avadi MR, Sadeghi AM, M Mohammadpour. 2009. Preparation and characterization of insulin nanoparticles using chitosan and arabic gum with ionic gelation metod. Journal Nanomeicine: 6. 58-63.
[03] Benerjee T, Mitra S, Singh AK, Sharma RK, Maitra A. 2002. Preparation, characterization, biodistribution of ultrafine chitosan nanoparticles. International Journal of Pharmaceutics. 243. 93-105.
[04] Desai KGH, Park HJ. 2005. Preparation and characterization of drug-loaded chitosan-tripolyphosphate microspheres by spray drying. Journal Drug Development Research. 64: 114-128.
[05] Franz H. 2005. Phosphatdylcholine treatment to induce lipolysis. Journal of Cosmetic Dermatology. 4: 308-313.
[06] Inayat BP, Mallikarjuna S. 2009. Chemical penetration enhancer for transdermal drug delivery systems. Tropical Journal of Pharmaceutical Research. 8: 173-179.
[07] Lee DW, Shirley SA, Lockey RF, Mohapatra SS. 2006. Thiolated chitosan nanoparticles enhace anti-inflammatory effects of intranasally delivered theophylline. Journal Medical Central. 7: 1-10.
[08] Mohanraj UJ, Chen Y. 2006. Nanoparticles – A Review. Tropical Journal of Pharmaceutical Research. 5 (1): 561-573.
[09] Murray RK, Ganner DK, Mayes PA, Rodwell VW. 2003. Harper’s Biochemistry. Melville: EGC.
[10] Ozguney IS, HY Karasulu, G Katarci, S Sozer, T Guneri, G Ertan. 2006. Transdermal delivery of diclofenac sodium though rat skin from various formulations. Journal Pharmaceutical Sciences Technology. 7(4): 88-103.
[11] Pebriani RH, Rilda Y, Zulhajri. 2012. Modifikasi Komposisi Kitosan Pada Proses Sintesis Komposit TiO2 – Kitosan. Jurnal Kimia Universitas Padjajaran. 1: 12-34.
[12] Rawling AV. 2006. Cellulite and its treatment. Journal Cosmetic Science. 28: 175-190.
[13] Rona C, Carrera M, Berardesca E. 2006. Testing anticellulite products. International Journal of Cosmetic Sciences. 28:169-173.
[14] Rossi ABR, Vergnanini AL. 2000. Cellulite. Journal of Pharmaceutical Research. 14: 121-262.
[15] Silva CM. 2006. Microencapsulation of hemoglobin in chitosan-coasted alginate microspheres prepared by emulsification internal gelation. Pharmaceutical Sciences Journal. 7 (4): 78-89.
[16] Silverstein RM, Webster FX, Kiemle DJ. 2005. Spectrometric identification of organic compounds. English: Willey Amazon.
[17] Sutriyo, Joshita D, Indah R. 2005. Perbandingan pelepasan propanol hidroklorida dari matriks kitosan, etil selulosa, dan hidroksipropil metal selulosa. Majalah Ilmu Kefarmasian. 2: 145-153.
[18] Tiyaboonchai W. 2003. Chitosan nanoparticles: a promosing system for drug delivery. Naresuan University Journal. 11 (3): 51-66.
[19] Wahyono D. 2010. Ciri nanopartikel kitosan dan pengaruhnya pada ukuran partikel dan efisiensi penyaluran ketoprofen [tesis]. Bogor (ID): Institut Pertanian Bogor.
[20] Wang X, Du Y, Liu H. 2004. Preparation, characterization, and antimicrobial activity of chitosan-Zn Complex. Journal of Medical Sciences. 56: 21-26.
[21] [WHO] World Health Organization. 2012. Cellulite [internet]. [diunduh 2012 April 8]. Tersedia pada http://www.who.int /mediacentre/ factsheets/ fs117/en/ index.html.
[22] Yongmei X, Yumm D. 2003. Effect of moleculer structure of chitosan on protein delivery properties of chitosan nanoparticles. International Journal of Pharmaceutics. 250: 215-226.
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