[01] Hossein Dahifar, Pediatric Department, Shohada Hospital Medical Center, Shahid Beheshti University of Medical Sciences and Health Services, Tehran, Iran. [02] Aboulfazl Ghorbani, Pathology Department, Noor Hospital, Tehran, Iran. [03] Mahta Fatemeh Basir, Pediatric Department, Shohada Hospital Medical Center, Tehran, Iran.

Background: Vitamin D deficiency is related to low sunlight exposure, diet, skin type, covering of the skin, use of sunscreens, aging and low dietary vitamin D and calcium intake and has long been recognized as a medical condition characterized by muscle weakness, bone pain and fragility fractures. Objective: To determine prevalence of 25-hydroxy vitamin D [25(OH) D] deficiency in lactating Islamic women and impact of vitamin D injection in deficient group. Methods: Baseline determination of serum calcium (Ca), phospherus (p), Alkaline- phosphatase (ALP), Parathyroid hormone (PTH) and 25 (OH) D levels in participants and according to their biochemical findings divided in three groups, sufficient, insufficient and deficient and intervention with 600000 IU vitamin D injection in deficient group and compare with baseline deficient group. Results: Participants included 286 lactating women with mean ages 28 years. 28 (9.7%) of participants were sufficient, 123 (43%) insufficient and 135 (47.2%) deficient according to their serum 25 (OH) D levels. Baseline mean ± SD serum 25 (OH) D and PTH in deficient and normal groups were 6.8 ± 2 ng/ml, 56.5 ± 45 pg/ml and 33.6 ± 0.8 ng/ml, 45.5 ± 15 pg/ml respectively. After intervention in deficient group serum PTH decreased and 25 [OH] D significantly increased. All serum Ca, P and ALP did not significantly altered. There were not significant differences in all variables between normal groups with after intervention in deficient group. Conclusion: Vitamin D deficiency is most prevalent in Iranian lactating Islamic women and can cause medical problem in future life if it is not prevented by supplementation and information to women and also if medical or health government authorities not pay attention to it.

Vitamin D, Sunlight Exposure, Parathyroid Hormone, Supplementation

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