[01] Rajeeva Lochana P., School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, India. [02] Maria Sharon Christy, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, India. [03] Bhavana Manjunatha, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu, India. [04] Ravi Theaj Prakash U., PG Department of Bioscience, CMR Institute of Management Studies, Bangalore, Karnataka, India.

Transdermal drugs or “patches” are preferred to oral drugs as it has pharmacological advantages over the oral route and improved patient acceptability and compliance. Salicylic acid being keratolytic is used on the skin to treat common skin diseases and foot warts. This study deals with the preparation of formulated gel using castor oil and salicylic acid. Formulation was prepared by mixing castor and nonyl phenol (surfactant). Evaluation of the formulated gel was observed for its appearance, homogeneity, pH, spreadability, drug content and antimicrobial activity. According to the obtained results, pH of castor with drug (6.9) was more efficient when compared to marketed gel (5.9), the formulated drug also showed good spreadability whereas, the drug content in marketed gel was more efficient. The formulations prepared i.e., castor oil alone as well as oil with the drug was found to be more effective and showed sensitivity towards certain bacteria and showed no effect towards fungal species. Therefore from the results obtained, formulated gel was more efficient than marketed gel.

Transdermal Drugs, Keratolytic, Surfactant, Castor Oil, Salicylic Acid

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