[01] Eduardo Padilla-Camberos, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México. [02] Ivan Moises Sanchez-Hernandez, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México. [03] Omar Ricardo Torres-Gonzalez, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México. [04] Nestor Emmanuel Diaz-Martinez, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México. [05] Sergio Sandoval-Avila, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México. [06] Mario Augusto Bolaños-Carrillo, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México.

Diabetes mellitus is a complex disease that involves various disorders related to the metabolism of macronutrients. It is characterized by chronic hyperglycemia that is a consequence of defects in the action and secretion of insulin. The treatment of diabetes leads to the use of drugs with notable side effects and alternatives have been sought through the use of various plant components. Agave fructans have shown in animal studies effects on the reduction of blood glucose. The objective of this study was to evaluate the anti-hyperglycemic activity of Agave tequilana fructans using in vitro and murine models to test optimal concentration and dose at several times to assure the biological effect of these compounds. The glucose release delay test was performed using dialysis membranes to identify the kinetics of glucose release. For the in vivo test, the study of postprandial hypoglycemic activity was performed. The results showed that Agave fructans decrease glucose absorption probably due to the delay in the release of glucose to the organism. Because of the above, Agave fructans could be used as food ingredients with the ability to control glucose levels in diabetic people.

Agave tequilana, Fructans, Hypoglycemic Activity

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