American Journal of Food Science and Health
Articles Information
American Journal of Food Science and Health, Vol.3, No.4, Aug. 2017, Pub. Date: Aug. 1, 2017
Anti-hyperglycemic Effects of Agave Fructans in Murine Model and in vitro Assay
Pages: 70-74 Views: 162 Downloads: 159
Authors
[01] Eduardo Padilla-Camberos, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México.
[02] Ivan Moises Sanchez-Hernandez, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México.
[03] Omar Ricardo Torres-Gonzalez, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México.
[04] Nestor Emmanuel Diaz-Martinez, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México.
[05] Sergio Sandoval-Avila, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México.
[06] Mario Augusto Bolaños-Carrillo, Medical and Pharmaceutical Biotechnology, Center for Research and Applied Technology in Jalisco, Guadalajara, Jalisco, México.
Abstract
Diabetes mellitus is a complex disease that involves various disorders related to the metabolism of macronutrients. It is characterized by chronic hyperglycemia that is a consequence of defects in the action and secretion of insulin. The treatment of diabetes leads to the use of drugs with notable side effects and alternatives have been sought through the use of various plant components. Agave fructans have shown in animal studies effects on the reduction of blood glucose. The objective of this study was to evaluate the anti-hyperglycemic activity of Agave tequilana fructans using in vitro and murine models to test optimal concentration and dose at several times to assure the biological effect of these compounds. The glucose release delay test was performed using dialysis membranes to identify the kinetics of glucose release. For the in vivo test, the study of postprandial hypoglycemic activity was performed. The results showed that Agave fructans decrease glucose absorption probably due to the delay in the release of glucose to the organism. Because of the above, Agave fructans could be used as food ingredients with the ability to control glucose levels in diabetic people.
Keywords
Agave tequilana, Fructans, Hypoglycemic Activity
References
[01] International Diabetes Federation. IDF (2016) Diabetes Atlas 7th ed http://www.diabetesatlas.org.
[02] Achi, N. K., Ohaeri, O. C., Ijeh, I. I., & Eleazu, C. (2016) Modulation of the lipid profile and insulin levels of streptozotocin induced diabetic rats by ethanol extract of Cnidoscolus aconitifolius leaves and some fractions: Effect on the oral glucose tolerance of normoglycemic rats, Biomedicine and Pharmacotheraphy, vol. 86, pp. 562-569.
[03] Patel, D. K., Kumar, R., Laloo, D., & Hemalatha, S. (2012) Diabetes mellitus: An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity, Asian Pacific Journal of Tropical Biomedicine, pp. 411-420.
[04] Ejike, C., Awazie, S., Nwangozi, P., & Godwin, C. (2013) Synergistic postprandial blood glucose modulatory properties of Vernonia amygdalina (Del.), Gongronema latifolium (Benth.) and Occimum gratissimum (Linn.) aqueous decoctions, Journal of Ethnopharmacology, vol. 149, pp. 111-116.
[05] Sharma, N., Sharma, V. K., & Seo, S. Y. (2005) Screening of some medicinal plants for anti-lipase activity, Journal of Ethnopharmacology,” vol. 97, pp. 453–456.
[06] Sairam S., &Urooj A. (2013) Artocarpus altilis mode of anti-hyperglycemic activity: elucidation by suitable in vitro and ex vivo techniques, International Journal of Pharmaceutical Sciences and Research, Vol. 4(8), pp. 3013-3019.
[07] Montañez, J., Venegas, J., & Vivar, M. (2011) Extracción, caracterización y cuantificación de los fructanos contenidos en la cabeza y en las hojas del Agave tequilana weber azul, Bioagro, Vol. 23(3), pp. 199-206.
[08] Vargas Vázquez, C. (2009) Obtención de insumos de interés industrial a partir de las fructanos del Agave mezcalero potosino Agave salmiana, CIIDIR-Michoacán, pp. 4-14.
[09] Urías, J., Cani, P., & Delmée. (2008) Physiological effects of dietary fructanos extracted from Agave tequilana Gto. and Dasylirion spp, British Journal of Nutrition, Vol. 99, pp. 254-261.
[10] Rendón, J., Juarez, B., & Pinos, J. (2012) Effects of differents Sources of Fructans on body weight, blood metabolites and fecal bacteria in normal and obese non-diabetic and diabetic rats, Plant Foods Human Nutrition, Vol. 67, pp. 64-70.
[11] Rendón Huerta, J. A., Juárez Flores, B. I., Pinos Rodríguez, J. M., Aguirre Rivera, J. R., & Delgado Portales, R. E. (2011). Effects of different kind of fructans on in vitro growth of Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium lactis, African journal of microbiology research, Vol. 5(n 18), pp. 2706-2710.
[12] Santos Zea, L., Leal Díaz, A. M., Cortés Ceballos, E., & Gutiérrez Uribe, J. A. (2012) Agave (Agave spp.) and its Traditional Products as a Source of Bioactive Compounds, Current Bioactive Compounds, Vol. 2012 (n 8), pp. 218-231.
[13] Márquez-Aguirre, A. L., Camacho-Ruiz, R. M., Arriaga-Alba, M., Padilla-Camberos, E., Kirchmayr, M. R., Blasco, J. L., & González-Avila, M. (2013) Effects of Agave tequilana fructans with different degree of polymerization profiles on the body weight, blood lipids and count of fecal Lactobacilli/Bifidobacteria in obese mice, Food & function, Vol. 4(n 8), pp. 1237-1244.
[14] Abirami, A., Nagarani, G., & Siddhuraju, P. (2014) Measurement of functional properties and health promoting aspects-glucose retardation index of peel, pulp and peel fiber from Citrus hystrix and Citrus maxima, Bioactive Carbohydrates and dietary fibre,” Science Direct, Vol. 4, pp. 16-26.
[15] Bhutkar, M., Bhise, S. (2013) In vitro hypoglycemic effects of Albizzia lebbeck and Mucuna pruriens, Asian Pacific Journal of Tropical Biomedicine, Vol. 3 (n 11), pp. 866-870.
[16] Ou S, Kwok KC, Li Y, Fu L. (2001) In vitro study of possible role of dietary fiber in lowering postprandial serum glucose, J Agric Food Chem, Vol. 49, pp.1026–1029.
[17] Céspedes, M. A. L., & Bustos, F. M. (2010) The effect of extruded orange pulp on enzymatic hydrolysis of starch and glucose retardation index,” Food and bioprocess technology, Vol. 3(n 5), pp. 684-692.
[18] Trinh, H. T., Han, S. J., Kim, S. W., Lee, Y. C., & Kim, D. H. (2007) Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng,” Journal of microbiology and biotechnology, Vol. 17(n 7), pp. 1127-1133.
[19] Choi, H. J., Kim, N. J., & Kim, D. H. (2000) Inhibitory effects of crude drugs on α-glucosidase, Archives of pharmaceutical research, Vol. 23(n 3), 261-266.
[20] Jaiswal, D., Rai, P., & Kumar, A. (2009) Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats, Journal of Ethnopharmacology, Vol. 129, pp. 392-396.
[21] Breuer, H. W. (2003) Review of acarbose therapeutic strategies in the long-term treatment and in the prevention of type 2 diabetes, International journal of clinical pharmacology and therapeutics, Vol. 41(n 10), pp. 421-440.
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