American Journal of Food Science and Health
Articles Information
American Journal of Food Science and Health, Vol.5, No.3, Sep. 2019, Pub. Date: Nov. 21, 2019
A Study on the Effect of Aspartame and Glucose on Post-Prandial Blood Glucose and Cognition
Pages: 158-166 Views: 226 Downloads: 170
Authors
[01] Caleb Chen Fan Tjuin, Department of Community Medicine, Faculty of Medicine, Melaka Manipal Medical College, Melaka, Malaysia.
[02] Aryani Najihah Binti Muhamed, Department of Community Medicine, Faculty of Medicine, Melaka Manipal Medical College, Melaka, Malaysia.
[03] Ayeshma Sathsarani Liyanage, Department of Community Medicine, Faculty of Medicine, Melaka Manipal Medical College, Melaka, Malaysia.
[04] Muhammad Danish Syahmi Bin Saha, Department of Community Medicine, Faculty of Medicine, Melaka Manipal Medical College, Melaka, Malaysia.
Abstract
Sugar substitutes play a big role in the lifestyle changes made by many individuals in an effort to control their blood sugar levels. One of the most popular substitute is Aspartame. The question this study seeks to resolve is, does Aspartame really work to produce a lower postprandial blood glucose level hence making it useful for glucose control in diabetes? And does Aspartame affect the mood, memory and concentration of a person differently than ‘table sugar’? A randomized control trial was conducted from August-September 2019 in a private medical college in Malaysia. Socio-demographic data, medical background, and mood scores were collected using a questionnaire. Blood glucose levels, before and after test sample consumptions, were measured using a glucometer. Participants also performed 3 computerized tests to assess their memory and concentration abilities. Mean, mean difference, various t-test (paired and unpaired) and p-values were calculated in the statistical analysis of the collected data. From a population of 300 students, we derived a sample size of 30 for which we received 40 volunteers – allowing for a 25% drop out rate. The results of our study were non-significant but indicate that consuming the intervention sample (Aspartame) resulted in a greater decrease in blood glucose levels than the control (Sucrose) sample. There was no significant difference in mood, memory and concentration either. The trend of our findings are coherent with the hypotheses of the study. All findings point to the effect use of Aspartame as a sugar substitute with no significant effects on mood, memory and concentration.
Keywords
Aspartame, Sucrose, Post-prandial, Sugar Substitutes
References
[01] Piernas C, Wang D, Du S, Zhang B, Wang Z, Su C, et al. The double burden of under- and overnutrition and nutrient adequacy among Chinese preschool and school-aged children in 2009-2011. European journal of clinical nutrition. U.S. National Library of Medicine; 2015.
[02] Center for Food Safety and Applied Nutrition. High-Intensity Sweeteners [Internet]. U.S. Food and Drug Administration. FDA; [cited 2019Sep3]. Available from: https://www.fda.gov/food/food-additives-petitions/high-intensity-sweeteners.
[03] Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Current hypertension reports. Springer US; 2018.
[04] Sylvetsky AC, Rother KI. Trends in the consumption of low-calorie sweeteners. Physiology & behavior. U.S. National Library of Medicine; 2016.
[05] Aspartame [Internet]. National Center for Biotechnology Information. PubChem Compound Database. U.S. National Library of Medicine; [cited 2019Sep3]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/134601.
[06] Whitehouse CR, Boullata J, McCauley LA. The potential toxicity of artificial sweeteners. AAOHN journal: official journal of the American Association of Occupational Health Nurses. U.S. National Library of Medicine; 2008.
[07] Center for Food Safety and Applied Nutrition. Additional Information about High-Intensity Sweeteners [Internet]. U.S. Food and Drug Administration. FDA; [cited 2019Sep3]. Available from: https://www.fda.gov/food/food-additives-petitions/additional-information-about-high-intensity-sweeteners-permitted-use-food-united-states.
[08] Aspartame [Internet]. European Food Safety Authority. [cited 2019Sep3]. Available from: https://www.efsa.europa.eu/en/topics/topic/aspartame.
[09] Dennis MJ, Wilson LA. NITRATES AND NITRITES. In: Encyclopedia of Food Sciences and Nutrition. 2nd ed. Academic Press; 2003. p. 4136–41.
[10] Rycerz K, Jaworska-Adamu JE. Review paper. Effects of aspartame metabolites on astrocytes and neurons. Folia Neuropathologica. Termedia; 2013.
[11] Saad A. A Review on Potential Toxicity of Artificial Sweetners vs Safety of Stevia: A Natural Bio-Sweetner. Journal of Biology, Agriculture and Healthcare.
[12] Phenylketonuria - Genetics Home Reference - NIH [Internet]. U.S. National Library of Medicine. National Institutes of Health; [cited 2019 Sep 3]. Available from: https://ghr.nlm.nih.gov/condition/phenylketonuria#.
[13] National Center for Biotechnology Information. PubChem Database. Aspartame, CID=134601, [cited Sept. 3, 2019] Available from: https://pubchem.ncbi.nlm.nih.gov/compound/134601.
[14] Soffritti M, Belpoggi F, Tibaldi E, Esposti DD, Lauriola M. Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats. Environmental health perspectives. National Institute of Environmental Health Sciences; 2007.
[15] Anton SD, Martin CK, Han H, Coulon S, Cefalu WT, Geiselman P, et al. Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite. U.S. National Library of Medicine; 2010.
[16] Romo-Romo A, Aguilar-Salinas CA, Brito-Córdova GX, Gómez Díaz RA, Vilchis Valentín D, Almeda-Valdes P. Effects of the Non-Nutritive Sweeteners on Glucose Metabolism and Appetite Regulating Hormones: Systematic Review of Observational Prospective Studies and Clinical Trials. PloS one. Public Library of Science; 2016.
[17] Harvey RA. Lippincott’s Illustrated Reviews; Biochemistry. 6th ed. New Delhi, Delhi: Wolters Kluwer; 2014.
[18] Sucrose [Internet]. National Center for Biotechnology Information. PubChem Compound Database. U.S. National Library of Medicine; Available from: https://pubchem.ncbi.nlm.nih.gov/compound/5988.
[19] The Canadian Sugar Institute [Internet]. The Canadian Sugar Institute. Available from: https://sugar.ca/Sugar-Basics/Sources-of-Sugar.aspx.
[20] Macdonald IA. A review of recent evidence relating to sugars, insulin resistance and diabetes. European journal of nutrition. Springer Berlin Heidelberg; 2016.
[21] Bray GA. Is Sugar Addictive? American Diabetes Association. 2016 Jun 21; 65 (7): 1797–9.
[22] Johnson RJ, Nakagawa T, Sanchez-Lozada LG, Shafiu M, Sundaram S, Le M, et al. Sugar, Uric Acid, and the Etiology of Diabetes and Obesity. Diabetes. American Diabetes Association; 2013.
[23] Lindseth GN, Coolahan SE, Petros TV, Lindseth PD. Neurobehavioral effects of aspartame consumption. Research in nursing & health. U.S. National Library of Medicine; 2014.
[24] Van der Zwaluw NL, van de Rest O, Kessels RPC, de Groot LCPGM. Short-term effects of glucose and sucrose on cognitive performance and mood in elderly people. Journal of clinical and experimental neuropsychology. U.S. National Library of Medicine; 2014.
600 ATLANTIC AVE, BOSTON,
MA 02210, USA
+001-6179630233
AIS is an academia-oriented and non-commercial institute aiming at providing users with a way to quickly and easily get the academic and scientific information.
Copyright © 2014 - American Institute of Science except certain content provided by third parties.