American Journal of Food Science and Health
Articles Information
American Journal of Food Science and Health, Vol.1, No.2, Jun. 2015, Pub. Date: May 28, 2015
Aquoeus Extracts of Celandine, Red Clover, Flax Seed and Coriander Inhibit Adenosine Deaminase Enzyme Activity in Cancerous Human Gastric Tissues
Pages: 51-56 Views: 1795 Downloads: 750
Authors
[01] Zahide E. Durak, Ordu University, Central Research Laboratory, Ordu, Turkey.
[02] Suleyman Buber, Ankara University Medical Faculty, Department of Biochemistry, Ankara, Turkey.
[03] Ender H. Kocaoglu, Ankara University Medical Faculty, Surgical Oncology Department, Ankara, Turkey.
[04] Bahadir Ozturk, Selçuk University Medical Faculty, Department of Biochemistry, Konya, Turkey.
Abstract
Background and Aim: Cancer is the major problem for all people in the world. The scientists have long been looking to natural remedies for the treatment of cancer because of side effects of chemotherapy and radiotherapy. Therefore we aimed to investigate possible effects of aquoeus extracts of Celandine (Chelidonium majus), Red Clover (Trifolium pratense), Flax seed (Linum usitatissimum) and Coriander (Coriandrum sativum) on adenosine deaminase (ADA) activity in cancerous and non cancerous human gastric and colon tissues. Materials and Methods: Cancerous and non cancerous human gastric (n=31) and colon tissues (n=19) removed by surgical operations were studied. The extracts were prepared in distilled water. Tissues were first homogenized in saline solution (20%, w/v), then centrifuged and supernatant fraction was used. In the tissue samples, adenosine deaminase activities were measured with and without plant extracts preincubated for 1 h. Results: It has been observed that aquoeus extracts of celandine, red clover, flax seed and coriander inhibit ADA enzyme in cancerous gastric tissues significantly, but none affects the enzyme in noncancerous gastric tissue. In the colon tissues, none of those except celandine affects the ADA activity. Celandine however activates the enzyme in both colon tissues significantly. Conclusion: It has been suggested that inhibition of ADA enzyme by celandine, red clover, flax seed and coriander extracts might give selective advantage to the cancerous tissues to combat cancer process. Clarification of ADA activation in colon tissues by celandine extract however needs further studies.
Keywords
Adenosine Deaminase, Cancer, Colon Tissue, Gastric Tissue, Chelidonium maju, Trifolium pratense, Linum usitatissimum, Coriandrum sativum
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