Physics Journal
Articles Information
Physics Journal, Vol.1, No.3, Nov. 2015, Pub. Date: Nov. 12, 2015
An Improved Predictive Assay for Radiotherapy to Human Hepatoma Measured by Prematurely Chromosome Condensation Technique
Pages: 290-294 Views: 1141 Downloads: 506
Authors
[01] Yang Jianshe, Life Science School, Longyan University, Longyan, China.
[02] Zhao Hua, Agricultural School, Gansu Agriculture University, Lanzhou, China.
Abstract
To investigate the radiation response of hepatoma, SMMC-7721 cells were irradiated with 60Co γ-rays. Initial chromatid breaks were measured by counting the number of chromatid breaks and isochromatid breaks. A dose-dependent increase in radiation-induced chromatid/isochromatid breaks was observed in G1 and G2 phase respectively. A good relationship was found between cell survival and chromatin breaks. This study implied that low LET radiation-induced chromatid/isochromatid breaks can be possibly used as a good predictor of radio sensitivity of SMMC-7721 hepatoma cells.
Keywords
Predictive Assay, Radiotherapy, Hepatoma, Prematurely Chromosome Condensation Technique
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